A
Aakash Basu
Researcher at Johns Hopkins University School of Medicine
Publications - 24
Citations - 683
Aakash Basu is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: DNA & Molecular motor. The author has an hindex of 12, co-authored 21 publications receiving 532 citations. Previous affiliations of Aakash Basu include Stanford University & National Centre for Biological Sciences.
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Journal ArticleDOI
Dynamics of Chromatin Decondensation Reveals the Structural Integrity of a Mechanically Prestressed Nucleus
Aprotim Mazumder,T. Roopa,Aakash Basu,Lakshminarayanan Mahadevan,G. V. Shivashankar,G. V. Shivashankar +5 more
TL;DR: The experiments on decondensation of chromatin in nuclei suggest that its compaction is a critical parameter in controlling nuclear stability and a simple theory based on a balance of forces in a swelling porous gel quantitatively explains the diffusive dynamics of swelling.
Journal ArticleDOI
Recent developments in single-molecule DNA mechanics
TL;DR: Recently, new magnetic tweezers approaches for simultaneously measuring freely fluctuating twist and extension have begun to shed light on the structural dynamics of large nucleoprotein complexes, contributing to a better understanding of abrupt structural transitions in mechanically stressed DNA as mentioned in this paper.
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Traffic of interacting ribosomes: effects of single-machine mechanochemistry on protein synthesis.
Aakash Basu,Debashish Chowdhury +1 more
TL;DR: A "unified" theoretical model is developed that not only incorporates the mutual exclusions of the interacting ribosomes, but also describes explicitly the mechanochemistry of each of these macromolecular machines during protein synthesis.
Journal ArticleDOI
Gold rotor bead tracking for high-speed measurements of DNA twist, torque and extension.
TL;DR: This work introduces gold rotor bead tracking (AuRBT), which enables direct measurements of DNA torque with >50× shorter integration times than previous techniques; it demonstrated high-resolution torque spectroscopy by mapping the conformational landscape of a Z-forming DNA sequence.
Journal ArticleDOI
Measuring DNA mechanics on the genome scale.
Aakash Basu,Aakash Basu,Dmitriy G. Bobrovnikov,Zan Qureshi,Tunc Kayikcioglu,Thuy T.M. Ngo,Anand Ranjan,Sebastian Eustermann,Basilio Cieza,Michael T. Morgan,Miroslav Hejna,H. Tomas Rube,Karl-Peter Hopfner,Cynthia Wolberger,Jun S. Song,Taekjip Ha +15 more
TL;DR: A high-throughput, chromosome-wide analysis of DNA looping reveals its contribution to the organization of chromatin, and provides insight into how nucleosomes are deposited and organised de novo.