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Anand Ranjan
Researcher at Johns Hopkins University
Publications - 28
Citations - 1621
Anand Ranjan is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Nucleosome & Histone. The author has an hindex of 15, co-authored 26 publications receiving 1341 citations. Previous affiliations of Anand Ranjan include National Institutes of Health & Howard Hughes Medical Institute.
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Journal ArticleDOI
Stepwise histone replacement by SWR1 requires dual activation with histone H2A.Z and canonical nucleosome.
TL;DR: It is shown that promoter-proximal nucleosomes are highly heterogeneous for H2A.Z in Saccharomyces cerevisiae, with substantial representation of nucleosome containing one, two, or zero H2a.Z molecules.
Journal ArticleDOI
Chz1, a Nuclear Chaperone for Histone H2AZ
Ed Luk,Ngoc Diep Vu,Kem Patteson,Gaku Mizuguchi,Wei Hua Wu,Anand Ranjan,Jonathon D. Backus,Subhojit Sen,Marc S. Lewis,Yawen Bai,Carl Wu +10 more
TL;DR: The discovery of Chz1 is reported, a histone chaperone that has preference for H2AZ and can also deliver a source of the histone variant for SWR1-dependent histone replacement.
Journal ArticleDOI
Nucleosome-free region dominates histone acetylation in targeting SWR1 to promoters for H2A.Z replacement.
Anand Ranjan,Gaku Mizuguchi,Peter C. FitzGerald,Debbie Wei,Feng Wang,Yingzi Huang,Ed Luk,Christopher L. Woodcock,Carl Wu,Carl Wu +9 more
TL;DR: Analysis of mutants indicates that the conserved Swc2/YL1 subunit and the adenosine triphosphatase domain of Swr1 are mainly responsible for binding to substrate, and SWR1 binding is enhanced on nucleosomes acetylated by the NuA4 histone acetyltransferase, but recognition of nucleosome-free and nucleosomal DNA is dominant over interaction with acetylation histones.
Journal ArticleDOI
Molecular architecture of the ATP-dependent chromatin-remodeling complex SWR1.
Vu Q. Nguyen,Anand Ranjan,Florian Stengel,Debbie Wei,Ruedi Aebersold,Ruedi Aebersold,Carl Wu,Carl Wu,Andres E. Leschziner +8 more
TL;DR: An important structural role for the Rvbs and a distinct substrate-handling mode by SWR1 is suggested, thereby providing a structural framework for understanding the complex dimer-exchange reaction.
Journal ArticleDOI
Rational Design of Fluorogenic and Spontaneously Blinking Labels for Super-Resolution Imaging.
Qinsi Zheng,Anthony X. Ayala,Inhee Chung,Aubrey V. Weigel,Anand Ranjan,Natalie Falco,Jonathan B. Grimm,Ariana N. Tkachuk,Carl Wu,Jennifer Lippincott-Schwartz,Robert H. Singer,Robert H. Singer,Luke D. Lavis +12 more
TL;DR: A quantitative framework for the development of new fluorogenic dyes is developed, determining that the lactone–zwitterion equilibrium constant (KL–Z) is sufficient to predict fluorogenicity.