C
Cynthia Wolberger
Researcher at Johns Hopkins University School of Medicine
Publications - 149
Citations - 14955
Cynthia Wolberger is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Ubiquitin & Histone. The author has an hindex of 55, co-authored 142 publications receiving 13615 citations. Previous affiliations of Cynthia Wolberger include Johns Hopkins University & Harvard University.
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Journal ArticleDOI
SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells
Marcia C. Haigis,Raul Mostoslavsky,Kevin M. Haigis,Kamau Fahie,Danos C. Christodoulou,Andrew J. Murphy,David M. Valenzuela,George D. Yancopoulos,Margaret Karow,Gil Blander,Cynthia Wolberger,Tomas A. Prolla,Richard Weindruch,Frederick W. Alt,Leonard Guarente +14 more
TL;DR: It is shown that SIRT4 functions in beta cell mitochondria to repress the activity of GDH by ADP-ribosylation, thereby downregulating insulin secretion in response to amino acids, effects that are alleviated during CR.
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Nampt/PBEF/visfatin regulates insulin secretion in β cells as a systemic NAD biosynthetic enzyme
Javier R. Revollo,Antje Körner,Kathryn F. Mills,Akiko Satoh,Tao Wang,Antje Garten,Biplab Dasgupta,Yo Sasaki,Cynthia Wolberger,Raymond R. Townsend,Jeffrey Milbrandt,Wieland Kiess,Shin-ichiro Imai +12 more
TL;DR: It is shown that eNampt does not exert insulin-mimetic effects in vitro or in vivo but rather exhibits robust NAD biosynthetic activity, suggesting a vital framework for the regulation of glucose homeostasis.
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A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.
Jeffrey S. Smith,Carrie Baker Brachmann,Carrie Baker Brachmann,Ivana Celic,Margaret A. Kenna,Margaret A. Kenna,Shabazz Muhammad,Vincent J. Starai,José L. Avalos,Jorge C. Escalante-Semerena,Charles Grubmeyer,Cynthia Wolberger,Jef D. Boeke +12 more
TL;DR: The yeast Sir2 protein, required for transcriptional silencing, has an NAD+dependent histone deacetylase (HDA) activity that is eliminated in a yeast strain from which SIR2 and its four homologs have been deleted as mentioned in this paper.
Journal ArticleDOI
The Biochemistry of Sirtuins
TL;DR: The chemical mechanism of sirtuins provides novel opportunities for signaling and metabolic regulation of protein deacetylation and the biological, chemical, and structural characteristics of these unusual enzymes are discussed.
Journal ArticleDOI
A standard reference frame for the description of nucleic acid base-pair geometry
Wilma K. Olson,Manju Bansal,Stephen K. Burley,Richard E. Dickerson,Mark Gerstein,Stephen C. Harvey,Udo Heinemann,Xiang-Jun Lu,Stephen Neidle,Zippora Shakked,Heinz Sklenar,Masashi Suzuki,Chang-Shung Tung,Eric Westhof,Cynthia Wolberger,Helen M. Berman +15 more
TL;DR: A common point of reference is needed to describe the three-dimensional arrangements of bases and base-pairs in nucleic acid structures and to pinpoint unique conformational features in individual structures.