A
Abdul Elkadri
Researcher at University of Toronto
Publications - 22
Citations - 1587
Abdul Elkadri is an academic researcher from University of Toronto. The author has contributed to research in topics: Inflammatory bowel disease & Exome sequencing. The author has an hindex of 14, co-authored 20 publications receiving 1285 citations.
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Journal ArticleDOI
The diagnostic approach to monogenic very early onset inflammatory bowel disease.
Holm H. Uhlig,Tobias Schwerd,Sibylle Koletzko,Neil Shah,Neil Shah,Jochen Kammermeier,Abdul Elkadri,Jodie Ouahed,Jodie Ouahed,David C. Wilson,David C. Wilson,Simon Travis,Dan Turner,Christoph Klein,Scott B. Snapper,Scott B. Snapper,Aleixo M. Muise +16 more
TL;DR: Key intestinal, extraintestinal, and laboratory features of 50 genetic variants associated with IBD-like intestinal inflammation are described and approaches for identifying patients likely to have these disorders are provided.
Journal ArticleDOI
Mutations in Tetratricopeptide Repeat Domain 7A Result in a Severe Form of Very Early Onset Inflammatory Bowel Disease
Yaron Avitzur,Conghui Guo,Lucas A. Mastropaolo,Ehsan Bahrami,Hannah Chen,Zhen Zhao,Abdul Elkadri,Sandeep S. Dhillon,Ryan Murchie,Ramzi Fattouh,Hien Q. Huynh,Jennifer Walker,Paul W. Wales,Ernest Cutz,Yoichi Kakuta,Joel T. Dudley,Jochen Kammermeier,Fiona Powrie,Neil Shah,Christoph Walz,Michaela Nathrath,Daniel Kotlarz,Jacek Puchaka,Jonathan R. Krieger,Tomas Racek,Thomas Kirchner,Thomas D. Walters,John H. Brumell,Anne M. Griffiths,Nima Rezaei,Parisa Rashtian,Mehri Najafi,Maryam Monajemzadeh,Stephen C. Pelsue,Dermot P.B. McGovern,Holm H. Uhlig,Eric E. Schadt,Christoph Klein,Scott B. Snapper,Scott B. Snapper,Aleixo M. Muise +40 more
TL;DR: Defects in the phosphatidylinositol 4-kinase-TTC7A-EFR3 homolog B pathway are involved in the pathogenesis of VEOIBD.
Journal ArticleDOI
Loss of the Arp2/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease
Walter H. A. Kahr,Fred G. Pluthero,Abdul Elkadri,Neil Warner,Marko Drobac,Chang Hua Chen,Richard W. Lo,Ling Li,Ren Li,Qi Li,Cornelia Thoeni,Jie Pan,Gabriella Leung,Irene Lara-Corrales,Ryan Murchie,Ernest Cutz,Ronald M. Laxer,Julia Upton,Chaim M. Roifman,Rae S. M. Yeung,John H. Brumell,Aleixo M. Muise +21 more
TL;DR: The findings suggest that ARPC1 isoforms are not functionally interchangeable, and is associated with haematopoietic/immune symptoms affecting cell lineages where this isoform predominates.
Journal ArticleDOI
Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann-Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease.
Tobias Schwerd,Sumeet Pandey,Huei-Ting Yang,Katrin Bagola,Elisabeth Jameson,Jonathan Jung,Robin H. Lachmann,Neil Shah,Smita Y. Patel,Claire Booth,Heiko Runz,Gesche Düker,Ruth Bettels,Marianne Rohrbach,Subra Kugathasan,Helen Chapel,Satish Keshav,Abdul Elkadri,Nick Platt,Alexio M. Muise,Sibylle Koletzko,Ramnik J. Xavier,Thorsten Marquardt,Fiona Powrie,James E. Wraith,Mads Gyrd-Hansen,Frances M. Platt,Holm H. Uhlig +27 more
TL;DR: The data support the concept that genetic defects at different checkpoints of selective autophagy cause a shared outcome of CD-like immunopathology linking monogenic and polygenic forms of IBD.
Journal ArticleDOI
Defects in NADPH Oxidase Genes NOX1 and DUOX2 in Very Early Onset Inflammatory Bowel Disease.
PK Hayes,Sandeep S. Dhillon,Kim O’Neill,Cornelia Thoeni,Ken Y. Hui,Abdul Elkadri,Conghui H. Guo,Lidija Kovačič,Gabriella Aviello,Luis Alvarez,Anne M. Griffiths,Scott B. Snapper,Steven R. Brant,James H. Doroshow,Mark S. Silverberg,Inga Peter,Dermot P.B. McGovern,Judy H. Cho,John H. Brumell,Holm H. Uhlig,Billy Bourke,Billy Bourke,Aleixo M. Muise,Ulla G. Knaus,Ulla G. Knaus +24 more
TL;DR: This study identifies the first inactivating missense variants in NOX1 and DUOX2 associated with VEOIBD, indicating defective ROS production from intestinal epithelial cells constitutes a risk factor for developing VEO IBD.