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Daniel Kotlarz
Researcher at Ludwig Maximilian University of Munich
Publications - 76
Citations - 5213
Daniel Kotlarz is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Inflammatory bowel disease & Immunodeficiency. The author has an hindex of 24, co-authored 63 publications receiving 4265 citations. Previous affiliations of Daniel Kotlarz include Hochschule Hannover & Hannover Medical School.
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Journal ArticleDOI
Inflammatory bowel disease and mutations affecting the interleukin-10 receptor.
Erik-Oliver Glocker,Daniel Kotlarz,Kaan Boztug,E. Michael Gertz,Alejandro A. Schäffer,Fatih Noyan,Mario Perro,Jana Diestelhorst,Anna Allroth,Dhaarini Murugan,Nadine Hätscher,Dietmar Pfeifer,Karl-Walter Sykora,Martin Sauer,Hans Kreipe,Martin Lacher,Rainer Nustede,Cristina Woellner,Ulrich Baumann,Ulrich Salzer,Sibylle Koletzko,Neil Shah,Anthony W. Segal,Axel Sauerbrey,Stephan Buderus,Scott B. Snapper,Bodo Grimbacher,Christoph Klein +27 more
TL;DR: Mutations in genes encoding the IL10R subunit proteins were found in patients with early-onset enterocolitis, involving hyperinflammatory immune responses in the intestine, and resulted in disease remission in one patient.
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The Transforming Growth Factor-β Superfamily Member Growth-Differentiation Factor-15 Protects the Heart From Ischemia/Reperfusion Injury
Tibor Kempf,Matthias Eden,Jens Strelau,Marian Naguib,Christian Willenbockel,Jörn Tongers,Jörg Heineke,Daniel Kotlarz,Jian Xu,Jeffery D. Molkentin,Hans W.M. Niessen,Helmut Drexler,Kai C. Wollert +12 more
TL;DR: Induction of GDF-15 in the heart is identified as a novel defense mechanism that protects from I/R injury and limits myocardial tissue damage in vivo.
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Statin-Induced Improvement of Endothelial Progenitor Cell Mobilization, Myocardial Neovascularization, Left Ventricular Function, and Survival After Experimental Myocardial Infarction Requires Endothelial Nitric Oxide Synthase
Ulf Landmesser,Niels Engberding,Ferdinand H. Bahlmann,Arnd Schaefer,Antje Wiencke,Andre Heineke,Stephan Spiekermann,Denise Hilfiker-Kleiner,Christian Templin,Daniel Kotlarz,Maja Mueller,Martin Fuchs,Burkhard Hornig,Hermann Haller,Helmut Drexler +14 more
TL;DR: It is suggested that increased eNO availability is required for statin-induced improvement of endothelial progenitor cell mobilization, myocardial neovascularization, LV dysfunction, interstitial fibrosis, and survival after MI.
Journal ArticleDOI
Loss of interleukin-10 signaling and infantile inflammatory bowel disease: implications for diagnosis and therapy.
Daniel Kotlarz,Daniel Kotlarz,Rita Beier,Dhaarini Murugan,Dhaarini Murugan,Jana Diestelhorst,Jana Diestelhorst,Ole Jensen,Ole Jensen,Kaan Boztug,Dietmar Pfeifer,Hans Kreipe,Eva Doreen Pfister,Ulrich Baumann,Jacek Puchałka,Jens Bohne,Odul Egritas,Buket Dalgic,Kaija-Leena Kolho,Axel Sauerbrey,Stephan Buderus,Tayfun Güngör,Axel Enninger,Yu Kar Ling Koda,Graziella Guariso,Batia Weiss,Selim Corbacioglu,Piotr Socha,Nuray Uslu,Ayse Metin,Ghassan Wahbeh,Khalid Husain,Dina Ramadan,Waleed Al Herz,Bodo Grimbacher,Martin Sauer,Karl Walter Sykora,Sibylle Koletzko,Christoph Klein,Christoph Klein +39 more
TL;DR: It is indicated that infantile IBD patients with perianal disease should be screened for IL-10 and IL-11R deficiency and that allogeneic HSCT can induce remission in those with IL- 10R deficiency.
Journal ArticleDOI
The phenotype of human STK4 deficiency
Hengameh Abdollahpour,Giridharan Appaswamy,Daniel Kotlarz,Daniel Kotlarz,Jana Diestelhorst,Jana Diestelhorst,Rita Beier,Alejandro A. Schäffer,E. Michael Gertz,Axel Schambach,Hans Kreipe,Dietmar Pfeifer,Karin R. Engelhardt,Nima Rezaei,Bodo Grimbacher,Sabine Lohrmann,Roya Sherkat,Christoph Klein,Christoph Klein +18 more
TL;DR: A novel clinical phenotype associating T- and B-cell lymphopenia, intermittent neutropenia, and atrial septal defects in 3 members of a consanguineous kindred is described.