K
Ken Y. Hui
Researcher at Yale University
Publications - 11
Citations - 4805
Ken Y. Hui is an academic researcher from Yale University. The author has contributed to research in topics: Genome-wide association study & Medicine. The author has an hindex of 7, co-authored 7 publications receiving 4128 citations.
Papers
More filters
Journal ArticleDOI
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
Luke Jostins,Stephan Ripke,Rinse K. Weersma,Richard H. Duerr,Dermot P.B. McGovern,Ken Y. Hui,James Lee,L. Philip Schumm,Yashoda Sharma,Carl A. Anderson,Jonah Essers,Mitja Mitrovic,Kaida Ning,Isabelle Cleynen,Emilie Theatre,Sarah L. Spain,Soumya Raychaudhuri,Philippe Goyette,Zhi Wei,Clara Abraham,Jean-Paul Achkar,Tariq Ahmad,Leila Amininejad,Ashwin N. Ananthakrishnan,Vibeke Andersen,Jane M. Andrews,Leonard Baidoo,Tobias Balschun,Peter A. Bampton,Alain Bitton,Gabrielle Boucher,Stephan Brand,Carsten Büning,Ariella Cohain,Sven Cichon,Mauro D'Amato,Dirk De Jong,Kathy L Devaney,Marla Dubinsky,Cathryn Edwards,David Ellinghaus,Lynnette R. Ferguson,Denis Franchimont,Karin Fransen,Richard B. Gearry,Michel Georges,Christian Gieger,Jürgen Glas,Talin Haritunians,Ailsa Hart,Christopher J. Hawkey,Matija Hedl,Xinli Hu,Tom H. Karlsen,Limas Kupčinskas,Subra Kugathasan,Anna Latiano,Debby Laukens,Ian C. Lawrance,Charlie W. Lees,Edouard Louis,Gillian Mahy,John C. Mansfield,Angharad R. Morgan,Craig Mowat,William G. Newman,Orazio Palmieri,Cyriel Y. Ponsioen,Uroš Potočnik,Natalie J. Prescott,Miguel Regueiro,Jerome I. Rotter,Richard K Russell,Jeremy D. Sanderson,Miquel Sans,Jack Satsangi,Stefan Schreiber,Lisa A. Simms,Jurgita Sventoraityte,Stephan R. Targan,Kent D. Taylor,Mark Tremelling,Hein W. Verspaget,Martine De Vos,Cisca Wijmenga,David C. Wilson,Juliane Winkelmann,Ramnik J. Xavier,Sebastian Zeissig,Bin Zhang,Clarence K. Zhang,Hongyu Zhao,Mark S. Silverberg,Vito Annese,Hakon Hakonarson,Steven R. Brant,Graham L. Radford-Smith,Christopher G. Mathew,John D. Rioux,Eric E. Schadt,Mark J. Daly,Andre Franke,Miles Parkes,Severine Vermeire,Jeffrey C. Barrett,Judy H. Cho +105 more
TL;DR: A meta-analysis of Crohn’s disease and ulcerative colitis genome-wide association scans is undertaken, followed by extensive validation of significant findings, with a combined total of more than 75,000 cases and controls.
Journal ArticleDOI
Functional variants in the LRRK2 gene confer shared effects on risk for Crohn's disease and Parkinson's disease.
Ken Y. Hui,Heriberto Fernandez-Hernandez,Jianzhong Hu,Adam Schaffner,Nathan Pankratz,Nai Yun Hsu,Ling-Shiang Chuang,Shai Carmi,Nicole Villaverde,Xianting Li,Manual Rivas,Manual Rivas,Adam P. Levine,Xiuliang Bao,Philippe R Labrias,Talin Haritunians,Darren Ruane,Kyle Gettler,Ernie Chen,Dalin Li,Elena R. Schiff,Nikolas Pontikos,Nir Barzilai,Steven R. Brant,Susan B. Bressman,Adam S. Cheifetz,Lorraine N. Clark,Mark J. Daly,Mark J. Daly,Robert J. Desnick,Richard H. Duerr,Seymour Katz,Seymour Katz,Seymour Katz,Todd Lencz,Richard H. Myers,Harry Ostrer,Laurie J. Ozelius,Laurie J. Ozelius,Haydeh Payami,Yakov Peter,Yakov Peter,John D. Rioux,Anthony W. Segal,William K. Scott,Mark S. Silverberg,Jeffery M. Vance,Iban Ubarretxena-Belandia,Tatiana Foroud,Gil Atzmon,Gil Atzmon,Itsik Pe'er,Yiannis A. Ioannou,Dermot P.B. McGovern,Zhenyu Yue,Eric E. Schadt,Judy H. Cho,Judy H. Cho,Inga Peter +58 more
TL;DR: The presence of shared LRRK2 alleles in CD and PD provides refined insight into disease mechanisms and may have major implications for the treatment of these two seemingly unrelated diseases.
Journal ArticleDOI
Sequencing an Ashkenazi reference panel supports population-targeted personal genomics and illuminates Jewish and European origins
Shai Carmi,Ken Y. Hui,Ethan Kochav,Xinmin Liu,James Xue,Fillan Grady,Saurav Guha,Kinnari Upadhyay,Danny Ben-Avraham,Semanti Mukherjee,B. Monica Bowen,Tinu Thomas,Joseph Vijai,Marc Cruts,Guy Froyen,Diether Lambrechts,Stéphane Plaisance,Christine Van Broeckhoven,Philip Van Damme,Herwig Van Marck,Nir Barzilai,Ariel Darvasi,Kenneth Offit,Susan B. Bressman,Laurie J. Ozelius,Inga Peter,Judy H. Cho,Harry Ostrer,Gil Atzmon,Lorraine N. Clark,Todd Lencz,Itsik Pe'er +31 more
TL;DR: High-depth sequencing of 128 complete genomes of AJ controls finds AJ to be an even admixture of European and likely Middle Eastern origins, suggesting a predominantly Near Eastern source for the repopulation of Europe after the Last Glacial Maximum.
Journal ArticleDOI
Defects in NADPH Oxidase Genes NOX1 and DUOX2 in Very Early Onset Inflammatory Bowel Disease.
PK Hayes,Sandeep S. Dhillon,Kim O’Neill,Cornelia Thoeni,Ken Y. Hui,Abdul Elkadri,Conghui H. Guo,Lidija Kovačič,Gabriella Aviello,Luis Alvarez,Anne M. Griffiths,Scott B. Snapper,Steven R. Brant,James H. Doroshow,Mark S. Silverberg,Inga Peter,Dermot P.B. McGovern,Judy H. Cho,John H. Brumell,Holm H. Uhlig,Billy Bourke,Billy Bourke,Aleixo M. Muise,Ulla G. Knaus,Ulla G. Knaus +24 more
TL;DR: This study identifies the first inactivating missense variants in NOX1 and DUOX2 associated with VEOIBD, indicating defective ROS production from intestinal epithelial cells constitutes a risk factor for developing VEO IBD.
Journal ArticleDOI
A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn’s Disease and Human Gut Microbiome Composition
Dalin Li,Jean Paul Achkar,Talin Haritunians,Jonathan P. Jacobs,Ken Y. Hui,Mauro D'Amato,Stephan Brand,Graham L. Radford-Smith,Graham L. Radford-Smith,Graham L. Radford-Smith,Jonas Halfvarson,Jan Hendrik Niess,Jan Hendrik Niess,Subra Kugathasan,Carsten Büning,L. Philip Schumm,Lambertus Klei,Ashwin N. Ananthakrishnan,Guy Aumais,Guy Aumais,Leonard Baidoo,Marla Dubinsky,Marla Dubinsky,Claudio Fiocchi,Jürgen Glas,Raquel Milgrom,Deborah D. Proctor,Miguel Regueiro,Lisa A. Simms,Joanne M. Stempak,Stephan R. Targan,Leif Törkvist,Leif Törkvist,Yashoda Sharma,Bernie Devlin,James Borneman,Hakon Hakonarson,Ramnik J. Xavier,Ramnik J. Xavier,Mark J. Daly,Mark J. Daly,Steven R. Brant,John D. Rioux,John D. Rioux,Mark S. Silverberg,Judy H. Cho,Jonathan Braun,Dermot P.B. McGovern,Richard H. Duerr +48 more
TL;DR: The results suggest that an SLC39A8-dependent shift in the gut microbiome could explain its pleiotropic effects on multiple complex diseases including CD.