Abhishek V. Garg

TL;DR: This Review focuses on the recent advances that have been made regarding the transcriptional control of TH 17 cell plasticity and stability, as well as the effector functions of TH17 cells, and highlights the mechanisms of IL-17 signalling in mesenchymal and barrier epithelial tissues.

TL;DR: This review discusses both the activators and the inhibitors of IL-17 signal transduction, and also the physiological implications of these events, and highlights the surprisingly diverse means by which these regulators control expression ofIL-17-dependent inflammatory genes, as well as the major target cells that respond to IL- 17 signaling.

TL;DR: It is shown that IL-17 is produced by tongue-resident populations of γδ T cells and nTh17 cells in response to oropharyngeal candidiasis in mice.

TL;DR: OECs dominantly control IL-17R-dependent responses to OPC through regulation of BD3 expression, and Susceptibility in Il17raΔK13 mice correlated with expression of the antimicrobial peptide β-defensin 3 (BD3, Defb3).

TL;DR: It is demonstrated that the signaling intermediate MCPIP1 (also termed Regnase-1, encoded by Zc3h12a) is a feedback inhibitor of IL-17 receptor signal transduction, which results in a biologically relevant inhibition ofIL-17 signaling.