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Abigail Clements
Researcher at Imperial College London
Publications - 40
Citations - 1776
Abigail Clements is an academic researcher from Imperial College London. The author has contributed to research in topics: Effector & Klebsiella pneumoniae. The author has an hindex of 20, co-authored 35 publications receiving 1448 citations. Previous affiliations of Abigail Clements include McGill University & Monash University, Clayton campus.
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Journal ArticleDOI
Infection strategies of enteric pathogenic Escherichia coli
TL;DR: The molecular mechanisms that allow enteric E. coli to colonize and cause disease in the human host are examined and for two of the pathotypes that express a type 3 secretion system (T3SS) the complex interplay between translocated effectors and manipulation of host cell signaling pathways that occurs during infection are discussed.
Journal ArticleDOI
MrkH, a Novel c-di-GMP-Dependent Transcriptional Activator, Controls Klebsiella pneumoniae Biofilm Formation by Regulating Type 3 Fimbriae Expression
Jonathan J. Wilksch,Ji Yang,Abigail Clements,Jacinta L. Gabbe,Kirsty R. Short,Hanwei Cao,Rosalia Cavaliere,Catherine E. James,Cynthia B. Whitchurch,Mark A. Schembri,Mary L. C. Chuah,Zhao-Xun Liang,Odilia L. C. Wijburg,Adam Jenney,Trevor Lithgow,Richard A. Strugnell +15 more
TL;DR: It is demonstrated for the first time that c-di-GMP can function as an effector to stimulate the activity of a transcriptional activator, and explain how type 3 fimbriae expression is coordinated with other gene expression programs in K. pneumoniae to promote biofilm formation to implanted medical devices.
Journal ArticleDOI
Subversion of trafficking, apoptosis, and innate immunity by type III secretion system effectors
Benoit Raymond,Joanna C. Young,Mitchell A. Pallett,Robert G. Endres,Abigail Clements,Gad Frankel +5 more
TL;DR: This review focuses on effectors that subvert signaling pathways that impact on endosomal trafficking, cell survival, and innate immunity, particularly phagocytosis, nuclear factor-κB, and mitogen-activated protein (MAP) kinase pathways and the inflammasome.
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Secondary acylation of Klebsiella pneumoniae lipopolysaccharide contributes to sensitivity to antibacterial peptides.
Abigail Clements,Dedreia Tull,Adam Jenney,Jacinta L. Farn,Sang-Hyun Kim,Russell E. Bishop,Joseph B. McPhee,Robert E. W. Hancock,Elizabeth L. Hartland,Elizabeth L. Hartland,Martin J. Pearse,Odilia L. C. Wijburg,David C. Jackson,Malcolm J. McConville,Richard A. Strugnell +14 more
TL;DR: The view that lipopolysaccharide acylation plays a important role in providing Gram-negative bacteria some resistance to structural and innate defenses and especially the antibacterial properties of detergents and cationic defensins is supported.
Journal ArticleDOI
The major surface-associated saccharides of Klebsiella pneumoniae contribute to host cell association.
Abigail Clements,Fabien Gaboriaud,Jérôme F. L. Duval,Jacinta L. Farn,Adam Jenney,Trevor Lithgow,Odilia L. C. Wijburg,Elizabeth L. Hartland,Richard A. Strugnell +8 more
TL;DR: A series of Klebsiella pneumoniae mutants in which the two major polysaccharide layers were absent or truncated was utilised to investigate the ability of these layers to protect against innate immune mechanisms and to associate with eukaryotic cells.