J
Jonathan J. Wilksch
Researcher at University of Melbourne
Publications - 37
Citations - 2084
Jonathan J. Wilksch is an academic researcher from University of Melbourne. The author has contributed to research in topics: Klebsiella pneumoniae & Bacterial outer membrane. The author has an hindex of 18, co-authored 34 publications receiving 1604 citations. Previous affiliations of Jonathan J. Wilksch include Monash University, Clayton campus & Discovery Institute.
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Journal ArticleDOI
Genomic analysis of diversity, population structure, virulence, and antimicrobial resistance in Klebsiella pneumoniae, an urgent threat to public health
Kathryn E. Holt,Heiman F. L. Wertheim,Ruth N. Zadoks,Stephen Baker,Chris A. Whitehouse,David A. B. Dance,Adam Jenney,Thomas R. Connor,Li Yang Hsu,Juliëtte A. Severin,Sylvain Brisse,Hanwei Cao,Jonathan J. Wilksch,Claire L. Gorrie,Mark B. Schultz,David J. Edwards,Kinh Van Nguyen,Trung Vu Nguyen,Trinh Tuyet Dao,Martijn Mensink,Vien Le Minh,Nguyen Thi Khanh Nhu,Constance Schultsz,Kuntaman Kuntaman,Paul N. Newton,Paul N. Newton,Catrin E. Moore,Catrin E. Moore,Richard A. Strugnell,Nicholas R. Thomson,Nicholas R. Thomson +30 more
TL;DR: The DNA sequence of K. pneumoniae isolates from around the world is determined and it is shown that there is a wide spectrum of diversity, including variation within shared sequences and gain and loss of whole genes, and there is an unrecognized association between the possession of specific gene profiles associated with virulence and antibiotic resistance.
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MrkH, a Novel c-di-GMP-Dependent Transcriptional Activator, Controls Klebsiella pneumoniae Biofilm Formation by Regulating Type 3 Fimbriae Expression
Jonathan J. Wilksch,Ji Yang,Abigail Clements,Jacinta L. Gabbe,Kirsty R. Short,Hanwei Cao,Rosalia Cavaliere,Catherine E. James,Cynthia B. Whitchurch,Mark A. Schembri,Mary L. C. Chuah,Zhao-Xun Liang,Odilia L. C. Wijburg,Adam Jenney,Trevor Lithgow,Richard A. Strugnell +15 more
TL;DR: It is demonstrated for the first time that c-di-GMP can function as an effector to stimulate the activity of a transcriptional activator, and explain how type 3 fimbriae expression is coordinated with other gene expression programs in K. pneumoniae to promote biofilm formation to implanted medical devices.
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Influenza A virus facilitates Streptococcus pneumoniae transmission and disease
Dimitri A. Diavatopoulos,Kirsty R. Short,John T. Price,Jonathan J. Wilksch,Lorena E. Brown,David E. Briles,Richard A. Strugnell,Odilia L. C. Wijburg +7 more
TL;DR: Using a novel animal model, novel insights are provided into pneumococcal‐influenza synergism and may indicate a previously unappreciated role of IAV in the spread of S. pneumoniae.
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Systematic analysis and prediction of type IV secreted effector proteins by machine learning approaches.
Jiawei Wang,Bingjiao Yang,Yi An,Tatiana T. Marquez-Lago,André Leier,Jonathan J. Wilksch,Qingyang Hong,Yang Zhang,Morihiro Hayashida,Tatsuya Akutsu,Geoffrey I. Webb,Richard A. Strugnell,Jiangning Song,Trevor Lithgow +13 more
TL;DR: A state-of-the-art T4SE predictor is developed by conducting a comprehensive performance evaluation of different machine learning algorithms along with a detailed analysis of single- and multi-feature selections.
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Role of Capsular Polysaccharides in Biofilm Formation: An AFM Nanomechanics Study
TL;DR: N nanomechanical measurements of wild type and specific mutants of the pathogen, Klebsiella pneumoniae, were performed in situ using atomic force microscopy (AFM) andoretical modeling shows that the organization of the capsule can influence bacterial adhesion, and thereby biofilm formation.