A
Abirami Lakshmanan
Researcher at University of Massachusetts Medical School
Publications - 7
Citations - 3980
Abirami Lakshmanan is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Zinc finger nuclease & Gene. The author has an hindex of 7, co-authored 7 publications receiving 3379 citations. Previous affiliations of Abirami Lakshmanan include Harvard University & The Forsyth Institute.
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Journal ArticleDOI
The Human Oral Microbiome
Floyd E. Dewhirst,Floyd E. Dewhirst,Tuste Chen,Jacques Izard,Jacques Izard,Bruce J. Paster,Bruce J. Paster,Anne C.R. Tanner,Anne C.R. Tanner,Wen-Han Yu,Abirami Lakshmanan,William G. Wade,William G. Wade +12 more
TL;DR: The HOMD is the first curated description of a human-associated microbiome and provides tools for use in understanding the role of the microbiome in health and disease.
Journal ArticleDOI
The Human Oral Microbiome Database: a web accessible resource for investigating oral microbe taxonomic and genomic information
TL;DR: The goal of creating the Human Oral Microbiome Database (HOMD) is to provide the scientific community with a body site-specific comprehensive database for the more than 600 prokaryote species that are present in the human oral cavity based on a curated 16S rRNA gene-based provisional naming scheme.
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miR-221 Is Required for Endothelial Tip Cell Behaviors during Vascular Development
Stefania Nicoli,Carl-Philipp Knyphausen,Carl-Philipp Knyphausen,Lihua Julie Zhu,Abirami Lakshmanan,Nathan D. Lawson +5 more
TL;DR: Deep sequencing and functional screening in zebrafish finds that miR-221 is essential for angiogenesis, and is identified as an important regulatory node through which tip cell migration and proliferation are controlled duringAngiogenesis.
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An optimized two-finger archive for ZFN-mediated gene targeting
Ankit Gupta,Ryan G. Christensen,Amy L. Rayla,Abirami Lakshmanan,Gary D. Stormo,Scot A. Wolfe +5 more
TL;DR: A set of validated two-finger modules are described that complement existing finger archives and expand the range of ZFN-accessible sequences threefold and introduced lesions at 9 of 11 target sites in the zebrafish genome.
Journal ArticleDOI
Evaluation and application of modularly assembled zinc-finger nucleases in zebrafish.
Cong Zhu,Tom Smith,Joseph C. McNulty,Amy L. Rayla,Abirami Lakshmanan,Arndt F. Siekmann,Matthew Buffardi,Xiangdong Meng,Jimann Shin,Arun Padmanabhan,Daniel Cifuentes,Antonio J. Giraldez,A. Thomas Look,Jonathan A. Epstein,Nathan D. Lawson,Scot A. Wolfe +15 more
TL;DR: This work generates new germline mutations in eight different genes, confirming that this is a viable platform for heritable gene inactivation in vertebrates and highlights the benefit of a definitive reverse genetic strategy to reveal gene function.