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Achille P. Caputi
Researcher at University of Messina
Publications - 407
Citations - 19416
Achille P. Caputi is an academic researcher from University of Messina. The author has contributed to research in topics: Nitrotyrosine & Artery occlusion. The author has an hindex of 74, co-authored 405 publications receiving 18740 citations. Previous affiliations of Achille P. Caputi include Queen Mary University of London & University of Salerno.
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Zymosan-activated plasma induces paw oedema by nitric oxide and prostaglandin production
TL;DR: The results suggest that in paw oedema induced by zymosan-activated plasma, the inflammatory response is dependent on NO (for the early phase) and prostaglandins ( for the late phase); the effect of NO is likely to be mediated by a pathway which does not involve cyclic GMP.
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Protective effect of melatonin on cellular energy depletion mediated by peroxynitrite and poly (ADP‐ribose) synthetase activation in a non‐septic shock model induced by zymosan in the rat
TL;DR: The view that the antioxidant and antiinflammatory effect of melatonin is also correlated with the inhibition of peroxynitrite production and PARS activation is supported, which supports the view that melatonin may be a novel pharmacological approach to prevent cell injury in inflammation.
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Adverse drug events in emergency department population: a prospective Italian study.
Gianluca Trifirò,Gianfranco Calogero,Francesca Menniti Ippolito,Marco Cosentino,Rodolfo Giuliani,Anita Conforti,Mauro Venegoni,G. Mazzaglia,Achille P. Caputi +8 more
TL;DR: A study to determine ADE incidence and ADE‐related hospital admissions among emergency department (ED) visits, and to identify the risk factors for serious ADE leading to ED visit.
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Melatonin effects on inhibition of thirst and fever induced by lipopolysaccharide in rat.
Felice Nava,Gioacchino Calapai,Grabiella Facciolà,Salvatore Cuzzocrea,Gabriella Giuliani,Angela De Sarro,Achille P. Caputi +6 more
TL;DR: It is suggested that melatonin could exert its dipsogenic effects through a reduction of the free radical nitric oxide (NO.) whereas it may reduce body temperature by preventing an excessive formation of prostaglandins and cytokines.
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Treatment with a novel poly(ADP-ribose) glycohydrolase inhibitor reduces development of septic shock-like syndrome induced by zymosan in mice.
Tiziana Genovese,Rosanna Di Paola,Paolo Catalano,Jia He Li,Weizheng Xu,Edmond Massuda,Achille P. Caputi,Jie Zhang,Salvatore Cuzzocrea +8 more
TL;DR: Evidence that GPI 18214, a PARG inhibitor, attenuates the degree of zymosan-induced nonseptic shock in mice, suggesting that PARG may be an alternative therapeutic target for shock treatment is provided.