A
Achille P. Caputi
Researcher at University of Messina
Publications - 407
Citations - 19416
Achille P. Caputi is an academic researcher from University of Messina. The author has contributed to research in topics: Nitrotyrosine & Artery occlusion. The author has an hindex of 74, co-authored 405 publications receiving 18740 citations. Previous affiliations of Achille P. Caputi include Queen Mary University of London & University of Salerno.
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Journal ArticleDOI
Calpain Inhibitor I Reduces the Development of Acute and Chronic Inflammation
Salvatore Cuzzocrea,Michelle C. McDonald,Emanuela Mazzon,Dilani Siriwardena,Ivana Serraino,Laura Dugo,Domenico Britti,Giuseppe Mazzullo,Achille P. Caputi,Christoph Thiemermann +9 more
TL;DR: Prevention of the activation of calpain I reduces the development of acute and chronic inflammation and may represent a novel therapeutic approach for the therapy of inflammation.
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Inhibition or knock out of Inducible nitric oxide synthase result in resistance to bleomycin-induced lung injury
Tiziana Genovese,Salvatore Cuzzocrea,Rosanna Di Paola,Marco Failla,Emanuela Mazzon,Maria Angela Sortino,Giuseppina Frasca,Elisa Gili,Nunzio Crimi,Achille P. Caputi,Carlo Vancheri +10 more
TL;DR: It is demonstrated that iNOS plays an important role in the lung injury induced by bleomycin in the mice by comparing the responses in wild-type and mice lacking (KO) the inducible nitric oxide synthase (iNOS).
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Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase, in a rodent model of lung injury
Salvatore Cuzzocrea,Michelle C. McDonald,Emanuela Mazzon,Laura Dugo,Ivana Serraino,Mike Threadgill,Achille P. Caputi,Christoph Thiemermann +7 more
TL;DR: Findings provide the first evidence that the activation of PARS participates in neutrophil-mediated lung injury by regulating the expression of P-selectin and ICAM-1.
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Effects of zileuton, a new 5-lipoxygenase inhibitor, in experimentally induced colitis in rats
TL;DR: It is shown that zileuton is effective in attenuating the lesions in an experimental model of colitis, consistent with the hypothesis that leukotrienes play an important role in the pathogenesis of intestinal bowel diseases (IBD).
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Inducible nitric oxide synthase-deficient mice exhibit resistance to the acute pancreatitis induced by cerulein.
Salvatore Cuzzocrea,Emanuela Mazzon,Laura Dugo,Ivana Serraino,Tommaso Centorrino,Antonio Ciccolo,Fons A. J. van de Loo,Domenico Britti,Achille P. Caputi,Christoph Thiemermann +9 more
TL;DR: Findings support the view that iNOS plays an important, pro-inflammatory role in the acute pancreatitis caused by cerulein in mice.