L
Laurence M. Brill
Researcher at Sanford-Burnham Institute for Medical Research
Publications - 37
Citations - 2281
Laurence M. Brill is an academic researcher from Sanford-Burnham Institute for Medical Research. The author has contributed to research in topics: Phosphorylation & Signal transduction. The author has an hindex of 24, co-authored 37 publications receiving 2097 citations. Previous affiliations of Laurence M. Brill include University of California, Los Angeles & Discovery Institute.
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Journal ArticleDOI
Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.
Arthur R. Salomon,Scott B. Ficarro,Laurence M. Brill,Achim Brinker,Qui T. Phung,Christer Ericson,Karsten Sauer,Ansgar Brock,David M. Horn,Peter G. Schultz,Eric C. Peters +10 more
TL;DR: A sensitive approach based on multidimensional liquid chromatography/mass spectrometry is described that enables the rapid identification of numerous sites of tyrosine phosphorylation on a number of different proteins from human whole cell lysates to enable the rapid generation of new insights into signaling pathways as they occur in states of health and disease.
Journal ArticleDOI
Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
Laurence M. Brill,Arthur R. Salomon,Scott B. Ficarro,Mridul Mukherji,Michelle Stettler-Gill,Eric C. Peters +5 more
TL;DR: It is shown that when using complex mixtures of peptides from human cells, methylation improved the selectivity of IMAC for phosphopeptides and eliminated the acidic bias that occurred with unmethylated peptides.
Journal ArticleDOI
Phosphoproteomic Analysis of Human Embryonic Stem Cells
Laurence M. Brill,Laurence M. Brill,Wen Xiong,Ki-Bum Lee,Scott B. Ficarro,Andrew Crain,Andrew Crain,Yue Xu,Alexey V. Terskikh,Evan Y. Snyder,Sheng Ding +10 more
TL;DR: The results support the utility of phosphoproteomic data, provide guidance for investigating protein function in hESCs, and complement transcriptomics/epigenetics for broadening the understanding of hESC fate determination.
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Control of Nutrient Stress-Induced Metabolic Reprogramming by PKCζ in Tumorigenesis
Li Ma,Yongzhen Tao,Angeles Duran,Victoria Llado,Anita Gálvez,Jennifer F. Barger,Elias A. Castilla,Jing Chen,Tomoko Yajima,Aleksey Porollo,Mario Medvedovic,Laurence M. Brill,David R. Plas,Stefan J. Riedl,Michael Leitges,Maria T. Diaz-Meco,Adam D. Richardson,Jorge Moscat +17 more
TL;DR: It is shown that PKCζ deficiency promotes the plasticity necessary for cancer cells to reprogram their metabolism to utilize glutamine through the serine biosynthetic pathway in the absence of glucose.
Journal ArticleDOI
Regulation of glutamine carrier proteins by RNF5 determines breast cancer response to ER stress-inducing chemotherapies.
Young Joo Jeon,Sihem Khelifa,Boris I. Ratnikov,David A. Scott,Yongmei Feng,Fabio Parisi,Chelsea Ruller,Eric Lau,Hyungsoo Kim,Laurence M. Brill,Tingting Jiang,David L. Rimm,Robert D. Cardiff,Gordon B. Mills,Jeffrey W. Smith,Andrei L. Osterman,Yuval Kluger,Ze'ev Ronai +17 more
TL;DR: Regulation of the L-glutamine carrier proteins SLC1A5 and SLC38A2 by the ubiquitin ligase RNF5 underlies BCa response to chemotherapies and indicates positive prognosis in BCa.