Adam Berrington

TL;DR: The results establish the feasibility of concurrent measurements of BOLD‐fMRI and neurochemicals using a novel combined fMRI‐MRS sequence and strengthen the link between glutamate and functional activity in the human brain by demonstrating a significant correlation of BALTIMATE and glutamate over time, and by showing ˜2% glutamate increases during 64 s of visual stimulation.

TL;DR: A novel two-voxel magnetic resonance spectroscopy approach is used to simultaneously quantify changes in neurochemicals within left and right M1s in healthy humans of both sexes in response to transcranial direct current stimulation (tDCS), shedding light on the interactions between the two major network nodes underpinning motor plasticity.

TL;DR: The harmonized sLASER protocol is expected to produce high reproducibility of MRS across sites thereby allowing large multi‐site studies with clinical cohorts and to evaluate the between‐vendor reproduCibility of its perfomance with phantoms and in vivo.

TL;DR: The study suggests that ebselen produces a functional inhibition of IMPase in the human brain, consistent with its reported ability to inhibit the enzyme, glutaminase.

TL;DR: Multisite multivendor single-voxel MR spectroscopy studies performed at 3.0 T can yield results that are coherent across vendors, provided that vendor differences in pulse sequence implementation are accounted for in data analysis, but the site-related effects on variability were more profound and suggest the need for further standardization of spectroscopic protocols.