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Adam F. Dukes
Researcher at Washington University in St. Louis
Publications - 4
Citations - 3477
Adam F. Dukes is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Genome & Myeloid leukemia. The author has an hindex of 4, co-authored 4 publications receiving 3289 citations. Previous affiliations of Adam F. Dukes include University of Washington.
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Journal ArticleDOI
Recurring mutations found by sequencing an acute myeloid leukemia genome.
Elaine R. Mardis,Li Ding,David J. Dooling,David E. Larson,Michael D. McLellan,Ken Chen,Daniel C. Koboldt,Robert S. Fulton,Kim D. Delehaunty,Sean McGrath,Lucinda Fulton,Devin P. Locke,Vincent Magrini,Rachel Abbott,Tammi L. Vickery,Jerry S. Reed,Jody S. Robinson,Todd Wylie,Scott M. Smith,Lynn K. Carmichael,James M. Eldred,Chris Harris,Jason Walker,Joshua Peck,Feiyu Du,Adam F. Dukes,Gabriel E. Sanderson,Anthony M. Brummett,Eric M. Clark,Joshua F. McMichael,Rick Meyer,Jonathan K. Schindler,Craig Pohl,John W. Wallis,Xiaoqi Shi,Ling Lin,Heather Schmidt,Yuzhu Tang,Carrie A. Haipek,Madeline E. Wiechert,Jolynda V. Ivy,Joelle Kalicki,Glendoria Elliott,Rhonda E. Ries,Jacqueline E. Payton,Peter Westervelt,Michael H. Tomasson,Mark A. Watson,Jack Baty,Sharon Heath,William D. Shannon,Rakesh Nagarajan,Daniel C. Link,Matthew J. Walter,Timothy A. Graubert,John F. DiPersio,Richard K. Wilson,Timothy J. Ley +57 more
TL;DR: By comparing the sequences of tumor and skin genomes of a patient with AML-M1, recurring mutations that may be relevant for pathogenesis are identified.
Journal ArticleDOI
Genome remodelling in a basal-like breast cancer metastasis and xenograft
Li Ding,Matthew J. Ellis,Shunqiang Li,David E. Larson,Ken Chen,John W. Wallis,Chris Harris,Michael D. McLellan,Robert S. Fulton,Lucinda Fulton,Rachel Abbott,Jeremy Hoog,David J. Dooling,Daniel C. Koboldt,Heather K. Schmidt,Joelle Kalicki,Qunyuan Zhang,Lei Chen,Ling Lin,Michael C. Wendl,Joshua F. McMichael,Vincent Magrini,Lisa Cook,Sean McGrath,Tammi L. Vickery,Elizabeth L. Appelbaum,Katherine DeSchryver,Sherri R. Davies,Therese Guintoli,Li-li Lin,Robert J. Crowder,Yu Long Tao,Jacqueline E. Snider,Scott M. Smith,Adam F. Dukes,Gabriel E. Sanderson,Craig Pohl,Kim D. Delehaunty,Catrina Fronick,Kimberley A. Pape,Jerry S. Reed,Jody S. Robinson,Jennifer S. Hodges,William Schierding,Nathan D. Dees,Dong-Wei Shen,Devin P. Locke,Madeline E. Wiechert,James M. Eldred,Josh B. Peck,Benjamin J. Oberkfell,Justin T. Lolofie,Feiyu Du,Amy Hawkins,Michelle D O'Laughlin,Kelly E. Bernard,Mark L. Cunningham,Glendoria Elliott,Mark D. Mason,Dominic M. Thompson,Jennifer Ivanovich,Paul J. Goodfellow,Charles M. Perou,George M. Weinstock,Rebecca Aft,Mark A. Watson,Timothy J. Ley,Richard K. Wilson,Elaine R. Mardis +68 more
TL;DR: The differential mutation frequencies and structural variation patterns in metastasis and xenograft compared with the primary tumour indicate that secondary tumours may arise from a minority of cells within thePrimary tumour.
Journal ArticleDOI
Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression
Lukas D. Wartman,David E. Larson,Zhifu Xiang,Zhifu Xiang,Li Ding,Ken Chen,Ling Lin,Patrick Cahan,Patrick Cahan,Jeffery M. Klco,John S. Welch,Cheng Li,Jacqueline E. Payton,Geoffrey L. Uy,Nobish Varghese,Rhonda E. Ries,Rhonda E. Ries,Mieke Hoock,Daniel C. Koboldt,Michael D. McLellan,Heather Schmidt,Robert S. Fulton,Rachel Abbott,Lisa Cook,Sean McGrath,Xian Fan,Adam F. Dukes,Tammi L. Vickery,Joelle Kalicki,Tamara Lamprecht,Timothy A. Graubert,Michael H. Tomasson,Elaine R. Mardis,Richard K. Wilson,Timothy J. Ley +34 more
TL;DR: In this article, the authors used a mouse model of APL, whereby PML-RARA expressed in myeloid cells leads to a myeloproliferative disease that ultimately evolves into APL.
Journal ArticleDOI
Genome Modeling System: A Knowledge Management Platform for Genomics.
Malachi Griffith,Obi L. Griffith,Scott M. Smith,Avinash Ramu,Matthew B. Callaway,Anthony M. Brummett,Michael J. Kiwala,Adam C. Coffman,Allison A. Regier,Benjamin J. Oberkfell,Gabriel E. Sanderson,Thomas P. Mooney,Nathaniel G. Nutter,Edward A. Belter,Feiyu Du,Robert T. L. Long,Travis E. Abbott,Ian T. Ferguson,David L. Morton,Mark M. Burnett,James V. Weible,Joshua Peck,Adam F. Dukes,Joshua F. McMichael,Justin T. Lolofie,Brian R. Derickson,Jasreet Hundal,Zachary L. Skidmore,Benjamin J. Ainscough,Nathan D. Dees,William Schierding,Cyriac Kandoth,Kyung H. Kim,Charles Lu,Chris Harris,Nicole Maher,Christopher G. Maher,Vincent Magrini,Benjamin S. Abbott,Ken Chen,Eric M. Clark,Indraniel Das,Xian Fan,Amy Hawkins,Todd G. Hepler,Todd Wylie,Shawn Leonard,William E. Schroeder,Xiaoqi Shi,Lynn K. Carmichael,Matthew R. Weil,Richard W. Wohlstadter,Gary Stiehr,Michael D. McLellan,Craig Pohl,Christopher A. Miller,Daniel C. Koboldt,Jason Walker,James M. Eldred,David E. Larson,David J. Dooling,Li Ding,Elaine R. Mardis,Richard K. Wilson +63 more
TL;DR: The GMS framework provides detailed tracking of samples and data coupled with reliable and repeatable analysis pipelines, allowing a large team to collaborate on data analysis, or an individual researcher to leverage the work of others effectively within its data management system.