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Benjamin J. Ainscough
Researcher at Washington University in St. Louis
Publications - 26
Citations - 2276
Benjamin J. Ainscough is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Cancer & Gene. The author has an hindex of 15, co-authored 24 publications receiving 1753 citations.
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CIViC is a community knowledgebase for expert crowdsourcing the clinical interpretation of variants in cancer
Malachi Griffith,Nicholas C. Spies,Kilannin Krysiak,Joshua F. McMichael,Adam C. Coffman,Arpad Danos,Benjamin J. Ainscough,Cody Ramirez,Damian T. Rieke,Lynzey Kujan,Erica K. Barnell,Alex H. Wagner,Zachary L. Skidmore,Amber Z. Wollam,Connor J. Liu,Martin R. Jones,Rachel L. Bilski,Robert Lesurf,Yan Yang Feng,Nakul M. Shah,Melika Bonakdar,Lee Trani,Matthew K. Matlock,Avinash Ramu,Katie M. Campbell,Gregory C. Spies,Aaron P. Graubert,Karthik Gangavarapu,James M. Eldred,David E. Larson,Jason Walker,Benjamin M. Good,Chunlei Wu,Andrew I. Su,Rodrigo Dienstmann,Adam A. Margolin,David Tamborero,Nuria Lopez-Bigas,Steven J.M. Jones,Ron Bose,David H. Spencer,Lukas D. Wartman,Richard K. Wilson,Elaine R. Mardis,Obi L. Griffith +44 more
TL;DR: CIViC is an expert-crowdsourced knowledgebase for Clinical Interpretation of Variants in Cancer describing the therapeutic, prognostic, diagnostic and predisposing relevance of inherited and somatic variants of all types.
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Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor
Dejan Juric,Pau Castel,Malachi Griffith,Obi L. Griffith,Helen Won,Haley Ellis,Saya H. Ebbesen,Benjamin J. Ainscough,Avinash Ramu,Gopa Iyer,Ronak Shah,Tiffany Huynh,Mari Mino-Kenudson,Dennis C. Sgroi,Steven J. Isakoff,Ashraf Thabet,Leila Elamine,David B. Solit,Scott W. Lowe,Cornelia Quadt,Malte Peters,Adnan Derti,Robert Schegel,Alan Huang,Elaine R. Mardis,Michael F. Berger,José Baselga,Maurizio Scaltriti +27 more
TL;DR: Tumour genomic evolution in a patient with metastatic breast cancer bearing an activating PIK3CA mutation is studied, concluding that parallel genetic evolution of separate metastatic sites with different PTEN genomic alterations leads to a convergent PTEN-null phenotype resistant to PI(3)Kα inhibition.
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DGIdb 2.0: mining clinically relevant drug-gene interactions.
Alex H. Wagner,Adam C. Coffman,Benjamin J. Ainscough,Nicholas C. Spies,Zachary L. Skidmore,Katie M. Campbell,Kilannin Krysiak,Deng Pan,Joshua F. McMichael,James M. Eldred,Jason Walker,Rick K. Wilson,Elaine R. Mardis,Malachi Griffith,Obi L. Griffith +14 more
TL;DR: Substantial updates have been made to increase content and improve its usefulness as a resource for mining clinically actionable drug targets, and a new web view and API have been developed to allow searching for interactions by drug identifiers to complement existing gene-based search functionality.
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High-performance web services for querying gene and variant annotation
Jiwen Xin,Adam Mark,Cyrus Afrasiabi,Ginger Tsueng,Moritz Juchler,Nikhil Gopal,Gregory S. Stupp,Timothy E. Putman,Benjamin J. Ainscough,Obi L. Griffith,Ali Torkamani,Patricia L. Whetzel,Christopher J. Mungall,Sean D. Mooney,Andrew I. Su,Chunlei Wu +15 more
TL;DR: This work describes MyGene.info and MyVariant.info, high-performance web services for querying gene and variant annotation information, and demonstrates a generalizable cloud-based model for organizing and querying biological annotation information.
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Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation.
John S. K. Kauwe,Matthew H. Bailey,Perry G. Ridge,Rachel Perry,Mark E. Wadsworth,Kaitlyn L. Hoyt,Lyndsay A. Staley,Celeste M. Karch,Oscar Harari,Carlos Cruchaga,Benjamin J. Ainscough,Kelly R. Bales,Eve H. Pickering,Sarah Bertelsen,Anne M. Fagan,Holtzman David M,John C. Morris,Alison Goate +17 more
TL;DR: The genetic associations reported here are novel and suggest mechanisms for genetic control of CSF and plasma levels of these disease-related proteins/pathways may be valuable therapeutic targets for AD.