J
John S. Welch
Researcher at Washington University in St. Louis
Publications - 129
Citations - 23128
John S. Welch is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Myeloid leukemia & Leukemia. The author has an hindex of 40, co-authored 115 publications receiving 19947 citations. Previous affiliations of John S. Welch include University of Washington & QIMR Berghofer Medical Research Institute.
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Journal ArticleDOI
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia
Timothy J. Ley,Christopher A. Miller,Li Ding,Benjamin J. Raphael,Andrew J. Mungall,Gordon Robertson,Katherine A. Hoadley,Timothy J. Triche,Peter W. Laird,Jack Baty,Lucinda Fulton,Robert S. Fulton,Sharon Heath,Joelle Kalicki-Veizer,Cyriac Kandoth,Jeffery M. Klco,Daniel C. Koboldt,Krishna L. Kanchi,Shashikant Kulkarni,Tamara Lamprecht,David E. Larson,G. Lin,Charles Lu,Michael D. McLellan,Joshua F. McMichael,Jacqueline E. Payton,Heather Schmidt,David H. Spencer,Michael H. Tomasson,John W. Wallis,Lukas D. Wartman,Mark A. Watson,John S. Welch,Michael C. Wendl,Adrian Ally,Miruna Balasundaram,Inanc Birol,Yaron S.N. Butterfield,Readman Chiu,Andy Chu,Eric Chuah,Hye Jung E. Chun,Richard Corbett,Noreen Dhalla,Ranabir Guin,An He,Carrie Hirst,Martin Hirst,Robert A. Holt,Steven J.M. Jones,Aly Karsan,Darlene Lee,Haiyan I. Li,Marco A. Marra,Michael Mayo,Richard A. Moore,Karen Mungall,Jeremy Parker,Erin Pleasance,Patrick Plettner,Jacquie Schein,Dominik Stoll,Lucas Swanson,Angela Tam,Nina Thiessen,Richard Varhol,Natasja Wye,Yongjun Zhao,Stacey Gabriel,Gad Getz,Carrie Sougnez,Lihua Zou,Mark D.M. Leiserson,Fabio Vandin,Hsin-Ta Wu,Frederick Applebaum,Stephen B. Baylin,Rehan Akbani,Bradley M. Broom,Ken Chen,Thomas C. Motter,Khanh Thi-Thuy Nguyen,John N. Weinstein,Nianziang Zhang,Martin L. Ferguson,Christopher Adams,Aaron D. Black,Jay Bowen,Julie M. Gastier-Foster,Thomas Grossman,Tara M. Lichtenberg,Lisa Wise,Tanja Davidsen,John A. Demchok,Kenna R. Mills Shaw,Margi Sheth,Heidi J. Sofia,Liming Yang,James R. Downing,Greg Eley,Shelley Alonso,Brenda Ayala,Julien Baboud,Mark Backus,Sean P. Barletta,Dominique L. Berton,Anna L. Chu,Stanley Girshik,Mark A. Jensen,Ari B. Kahn,Prachi Kothiyal,Matthew C. Nicholls,Todd Pihl,David Pot,Rohini Raman,Rashmi N. Sanbhadti,Eric E. Snyder,Deepak Srinivasan,Jessica Walton,Yunhu Wan,Zhining Wang,Jean Pierre J. Issa,Michelle M. Le Beau,Martin Carroll,Hagop M. Kantarjian,Steven M. Kornblau,Moiz S. Bootwalla,Phillip H. Lai,Hui Shen,David Van Den Berg,Daniel J. Weisenberger,Daniel C. Link,Matthew J. Walter,Bradley A. Ozenberger,Elaine R. Mardis,Peter Westervelt,Timothy A. Graubert,John F. DiPersio,Richard K. Wilson +138 more
TL;DR: It is found that a complex interplay of genetic events contributes to AML pathogenesis in individual patients and the databases from this study are widely available to serve as a foundation for further investigations of AMl pathogenesis, classification, and risk stratification.
Journal ArticleDOI
Mutational landscape and significance across 12 major cancer types
Cyriac Kandoth,Michael D. McLellan,Fabio Vandin,Kai Ye,Beifang Niu,Charles Lu,Mingchao Xie,Qunyuan Zhang,Joshua F. McMichael,Matthew A. Wyczalkowski,Mark D.M. Leiserson,Christopher A. Miller,John S. Welch,Matthew J. Walter,Michael C. Wendl,Timothy J. Ley,Richard K. Wilson,Benjamin J. Raphael,Li Ding +18 more
TL;DR: Data and analytical results for point mutations and small insertions/deletions from 3,281 tumours across 12 tumour types are presented as part of the TCGA Pan-Cancer effort, and clinical association analysis identifies genes having a significant effect on survival.
Journal ArticleDOI
Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing
Li Ding,Timothy J. Ley,David E. Larson,Christopher A. Miller,Daniel C. Koboldt,John S. Welch,Julie Ritchey,Margaret A. Young,Tamara Lamprecht,Michael D. McLellan,Joshua F. McMichael,John W. Wallis,Charles Lu,Dong Shen,Chris Harris,David J. Dooling,Robert S. Fulton,Lucinda Fulton,Ken Chen,Heather Schmidt,Joelle Kalicki-Veizer,Vincent Magrini,Lisa Cook,Sean McGrath,Tammi L. Vickery,Michael C. Wendl,Sharon Heath,Mark A. Watson,Daniel C. Link,Michael H. Tomasson,William D. Shannon,Jacqueline E. Payton,Shashikant Kulkarni,Peter Westervelt,Matthew J. Walter,Timothy A. Graubert,Elaine R. Mardis,Richard K. Wilson,John F. DiPersio +38 more
TL;DR: The sequenced primary tumour and relapse genomes from eight AML patients and validated hundreds of somatic mutations using deep sequencing demonstrated that AML relapse is associated with the addition of new mutations and clonal evolution, which is shaped by the chemotherapy that the patients receive to establish and maintain remissions.
Journal ArticleDOI
DNMT3A Mutations in Acute Myeloid Leukemia
Timothy J. Ley,Li Ding,Matthew J. Walter,Michael D. McLellan,Tamara Lamprecht,David E. Larson,Cyriac Kandoth,Jacqueline E. Payton,Jack Baty,John S. Welch,Chris Harris,Cheryl F. Lichti,R. Reid Townsend,Robert S. Fulton,David J. Dooling,Daniel C. Koboldt,Heather Schmidt,Qunyuan Zhang,John R. Osborne,Ling Lin,Michelle O'Laughlin,Joshua F. McMichael,Kim D. Delehaunty,Sean McGrath,Lucinda Fulton,Vincent Magrini,Tammi L. Vickery,Jasreet Hundal,Lisa Cook,Joshua J. Conyers,Gary W. Swift,Jerry P. Reed,Patricia A. Alldredge,Todd Wylie,Jason Walker,Joelle Kalicki,Mark A. Watson,Sharon Heath,William D. Shannon,Nobish Varghese,Rakesh Nagarajan,Peter Westervelt,Michael H. Tomasson,Daniel C. Link,Timothy A. Graubert,John F. DiPersio,Elaine R. Mardis,Richard K. Wilson +47 more
TL;DR: DNMT3A mutations are highly recurrent in patients with de novo AML with an intermediate-risk cytogenetic profile and are independently associated with a poor outcome in Cox proportional-hazards analysis.
Journal ArticleDOI
Age-related mutations associated with clonal hematopoietic expansion and malignancies
Mingchao Xie,Charles Lu,Jiayin Wang,Michael D. McLellan,Kimberly J. Johnson,Michael C. Wendl,Joshua F. McMichael,Heather Schmidt,Venkata Yellapantula,Christopher A. Miller,Bradley A. Ozenberger,John S. Welch,Daniel C. Link,Matthew J. Walter,Elaine R. Mardis,John F. DiPersio,Feng Chen,Richard K. Wilson,Timothy J. Ley,Li Ding +19 more
TL;DR: The analyses show that the blood cells of more than 2% of individuals contain mutations that may represent premalignant events that cause clonal hematopoietic expansion, and several recurrently mutated genes that may be disease initiators are identified.