A
Adam Faulconbridge
Researcher at European Bioinformatics Institute
Publications - 19
Citations - 2260
Adam Faulconbridge is an academic researcher from European Bioinformatics Institute. The author has contributed to research in topics: Induced pluripotent stem cell & Artificial life. The author has an hindex of 13, co-authored 19 publications receiving 1750 citations. Previous affiliations of Adam Faulconbridge include Natural Environment Research Council & University of York.
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Journal ArticleDOI
Comparative genomic analysis of three Leishmania species that cause diverse human disease
Christopher S. Peacock,Kathy Seeger,David Harris,Lee Murphy,Jeronimo C. Ruiz,Michael A. Quail,Nicholas S. Peters,Ellen Adlem,Adrian Tivey,Martin Aslett,Arnaud Kerhornou,Alasdair Ivens,Audrey Fraser,Marie-Adèle Rajandream,Tim Carver,Halina Norbertczak,Tracey Chillingworth,Zahra Hance,Kay Jagels,Sharon Moule,Doug Ormond,Simon Rutter,Rob Squares,Sally Whitehead,Ester Rabbinowitsch,Claire Arrowsmith,Brian White,Scott Thurston,Frédéric Bringaud,Sandra L. Baldauf,Adam Faulconbridge,Daniel C. Jeffares,Daniel P. Depledge,Samuel O. Oyola,James D. Hilley,Loislene O. Brito,Luiz R. O. Tosi,Barclay G. Barrell,Angela K. Cruz,Jeremy C. Mottram,Deborah F. Smith,Matthew Berriman +41 more
TL;DR: It is shown that pseudogene formation and gene loss are the principal forces shaping the different genomes of Leishmania, and genes that are differentially distributed between the species encode proteins implicated in host-pathogen interactions and parasite survival in the macrophage.
Journal ArticleDOI
Common genetic variation drives molecular heterogeneity in human iPSCs
Helena Kilpinen,Angela Goncalves,Andreas Leha,Vackar Afzal,Kaur Alasoo,Sofie Ashford,Sendu Bala,Dalila Bensaddek,Francesco Paolo Casale,Oliver J. Culley,Petr Danacek,Adam Faulconbridge,Peter W. Harrison,Annie Kathuria,Davis J. McCarthy,Davis J. McCarthy,Shane A. McCarthy,Ruta Meleckyte,Yasin Memari,Nathalie Moens,Filipa A.C. Soares,Alice L. Mann,Ian Streeter,Chukwuma A. Agu,Alex Alderton,Rachel Nelson,Sarah Harper,Minal Patel,A. White,Sharad R. Patel,Laura Clarke,Reena Halai,Christopher M. Kirton,Anja Kolb-Kokocinski,Philip L. Beales,Ewan Birney,Davide Danovi,Angus I. Lamond,Willem H. Ouwehand,Willem H. Ouwehand,Willem H. Ouwehand,Ludovic Vallier,Ludovic Vallier,Fiona M. Watt,Richard Durbin,Oliver Stegle,Daniel J. Gaffney +46 more
TL;DR: This study outlines the major sources of genetic and phenotypic variation in iPS cells and establishes their suitability as models of complex human traits and cancer.
Journal ArticleDOI
Open Targets Platform: new developments and updates two years on.
Denise Carvalho-Silva,Andrea Pierleoni,Miguel Pignatelli,Chuang Kee Ong,Luca Fumis,Nikiforos Karamanis,Miguel Carmona,Adam Faulconbridge,Andrew Hercules,Elaine McAuley,Alfredo Miranda,Gareth Peat,Michaela Spitzer,Jeffrey C. Barrett,David G. Hulcoop,Eliseo Papa,Gautier Koscielny,Ian Dunham +17 more
TL;DR: The latest developments of the Open Targets Platform are presented, expanding the evidence and target-disease associations with new and improved data sources, refining data quality, enhancing website usability, and increasing the user base with training workshops, user support, social media and bioinformatics forum engagement.
Journal ArticleDOI
Open Targets Platform: supporting systematic drug-target identification and prioritisation.
David Ochoa,Andrew Hercules,Miguel Carmona,Daniel Suveges,Asier Gonzalez-Uriarte,Cinzia Malangone,Alfredo Miranda,Luca Fumis,Denise Carvalho-Silva,Michaela Spitzer,Jarrod Baker,Javier Ferrer,Arwa Bin Raies,Olesya Razuvayevskaya,Adam Faulconbridge,Eirini Petsalaki,Prudence Mutowo,Sandra Machlitt-Northen,Gareth Peat,Elaine McAuley,Chuang Kee Ong,Edward Mountjoy,Maya Ghoussaini,Andrea Pierleoni,Eliseo Papa,Miguel Pignatelli,Gautier Koscielny,Mohd Anisul Karim,Jeremy Schwartzentruber,David G. Hulcoop,Ian Dunham,Ian Dunham,Ellen M. McDonagh +32 more
TL;DR: To aid the prioritisation of targets and inform on the potential impact of modulating a given target, evaluation of post-marketing adverse drug reactions and new curated information on target tractability and safety are added.
Journal ArticleDOI
Population differentiation and genetic variation in host choice among pea aphids from eight host plant genera.
Julia Ferrari,H. Charles J. Godfray,H. Charles J. Godfray,Adam Faulconbridge,Kim Prior,Sara Via +5 more
TL;DR: How a combination of host plant preference and mating on the host plant may promote local adaptation and possibly ecological speciation, and whether a widely accepted host could oppose speciation by mediating gene flow between different populations are discussed.