D
Doug Ormond
Researcher at Wellcome Trust Sanger Institute
Publications - 14
Citations - 6675
Doug Ormond is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 13, co-authored 13 publications receiving 6342 citations. Previous affiliations of Doug Ormond include Wellcome Trust.
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Journal ArticleDOI
The Genome of the African Trypanosome Trypanosoma brucei
Matthew Berriman,Elodie Ghedin,Elodie Ghedin,Christiane Hertz-Fowler,Gaëlle Blandin,Hubert Renauld,Daniella Castanheira Bartholomeu,Nicola Lennard,Elisabet Caler,N. Hamlin,Brian J. Haas,Ulrike Böhme,Linda Hannick,Martin Aslett,Joshua Shallom,Lucio Marcello,Lihua Hou,Bill Wickstead,U. Cecilia M. Alsmark,Claire Arrowsmith,Rebecca Atkin,Andrew Barron,Frédéric Bringaud,Karen Brooks,Mark Carrington,Inna Cherevach,Tracey-Jane Chillingworth,Carol Churcher,Louise Clark,Craig Corton,Ann Cronin,Robert L. Davies,Jonathon Doggett,Appolinaire Djikeng,Tamara Feldblyum,Mark C. Field,Audrey Fraser,Ian Goodhead,Zahra Hance,David Harper,Barbara Harris,Heidi Hauser,Jessica B. Hostetler,Al Ivens,Kay Jagels,David W. Johnson,Justin Johnson,Kristine Jones,Arnaud Kerhornou,Hean Koo,Natasha Larke,Scott M. Landfear,Christopher Larkin,Vanessa Leech,Alexandra Line,Angela Lord,Annette MacLeod,P. Mooney,Sharon Moule,David M. A. Martin,Gareth W. Morgan,Karen Mungall,Halina Norbertczak,Doug Ormond,Grace Pai,Christopher S. Peacock,Jeremy Peterson,Michael A. Quail,Ester Rabbinowitsch,Marie-Adèle Rajandream,Chris P Reitter,Steven L. Salzberg,Mandy Sanders,Seth Schobel,Sarah Sharp,Mark Simmonds,Anjana J. Simpson,Luke J. Tallon,C. Michael R. Turner,Andrew Tait,Adrian Tivey,Susan Van Aken,Danielle Walker,David Wanless,Shiliang Wang,Brian White,Owen White,Sally Whitehead,John Woodward,Jennifer R. Wortman,Mark Raymond Adams,T. Martin Embley,Keith Gull,Elisabetta Ullu,J. David Barry,Alan H. Fairlamb,Fred R. Opperdoes,Barclay G. Barrell,John E. Donelson,Neil Hall,Neil Hall,Claire M. Fraser,Sara E. Melville,Najib M. El-Sayed,Najib M. El-Sayed +104 more
TL;DR: Comparisons of the cytoskeleton and endocytic trafficking systems of Trypanosoma brucei with those of humans and other eukaryotic organisms reveal major differences.
Journal ArticleDOI
Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica.
Julian Parkhill,Mohammed Sebaihia,Andrew Preston,Lee Murphy,Nicholas R. Thomson,David Harris,Matthew T. G. Holden,Carol Churcher,Stephen D. Bentley,Karen Mungall,Ana Cerdeño-Tárraga,Louise M. Temple,Keith D. James,Barbara Harris,Michael A. Quail,Mark Achtman,Rebecca Atkin,Steven K. Baker,David Basham,Nathalie Bason,Inna Cherevach,Tracey Chillingworth,Matthew Collins,Anne Cronin,Paul Davis,Jonathan Doggett,Theresa Feltwell,Arlette Goble,N. Hamlin,Heidi Hauser,S. Holroyd,Kay Jagels,Sampsa Leather,Sharon Moule,Halina Norberczak,Susan O'Neil,Doug Ormond,Claire Price,Ester Rabbinowitsch,Simon Rutter,Mandy Sanders,David L. Saunders,Katherine Seeger,Sarah Sharp,Mark Simmonds,Jason Skelton,R. Squares,S. Squares,K. Stevens,Louise Unwin,Sally Whitehead,Bart Barrell,Duncan J. Maskell +52 more
TL;DR: The authors' analysis indicates that B. parapertussis and B. pertussis are independent derivatives of B. bronchiseptica-like ancestors; host adaptation seems to be a consequence of loss, not gain, of function, and differences in virulence may be related to loss of regulatory or control functions.
Journal ArticleDOI
A Comprehensive Survey of the Plasmodium Life Cycle by Genomic, Transcriptomic, and Proteomic Analyses
Neil Hall,Marianna Karras,J. Dale Raine,Jane M. Carlton,Jane M. Carlton,Jane M. Carlton,Taco W. A. Kooij,Matthew Berriman,Laurence Florens,Christoph S. Janssen,Arnab Pain,Georges K. Christophides,Keith D. James,Kim Rutherford,Barbara Harris,David Harris,Carol Churcher,Michael A. Quail,Doug Ormond,Jon Doggett,Holly E. Trueman,Jacqui Mendoza,Shelby L. Bidwell,Marie Adele Rajandream,Daniel J. Carucci,John R. Yates,Fotis C. Kafatos,Chris J. Janse,Bart Barrell,C. Michael R. Turner,Andrew P. Waters,Robert E. Sinden +31 more
TL;DR: It is observed posttranscriptional gene silencing through translational repression of messenger RNA during sexual development, and a 47-base 3′ untranslated region motif is implicated in this process.
Journal ArticleDOI
The genome of the protist parasite Entamoeba histolytica
Brendan J. Loftus,Iain J. Anderson,Robert L. Davies,U. Cecilia M. Alsmark,John Samuelson,Paolo Amedeo,Paola Roncaglia,Matthew Berriman,Robert P. Hirt,Barbara J. Mann,Tomo Nozaki,Bernard B. Suh,Mihai Pop,Michael Duchêne,John P. Ackers,Egbert Tannich,Matthias Leippe,Margit Hofer,Iris Bruchhaus,Ute Willhoeft,Alok Bhattacharya,Tracey Chillingworth,Carol Churcher,Zahra Hance,Barbara Harris,David Harris,Kay Jagels,Sharon Moule,Karen Mungall,Doug Ormond,Rob Squares,Sally Whitehead,Michael A. Quail,Ester Rabbinowitsch,Halina Norbertczak,Claire Price,Zheng Wang,Nancy Guillén,Carol A. Gilchrist,Suzanne Stroup,Sudha Bhattacharya,Anuradha Lohia,Peter G. Foster,Thomas Sicheritz-Pontén,Christian Weber,Upinder Singh,Chandrama Mukherjee,Najib M. El-Sayed,William A. Petri,C. Graham Clark,T. Martin Embley,Bart Barrell,Claire M. Fraser,Neil Hall,Neil Hall +54 more
TL;DR: The genome of E. histolytica is presented, which reveals a variety of metabolic adaptations shared with two other amitochondrial protist pathogens: Giardia lamblia and Trichomonas vaginalis, and provides new insights into the workings and genome evolution of a major human pathogen.
Journal ArticleDOI
Comparative genomic analysis of three Leishmania species that cause diverse human disease
Christopher S. Peacock,Kathy Seeger,David Harris,Lee Murphy,Jeronimo C. Ruiz,Michael A. Quail,Nicholas S. Peters,Ellen Adlem,Adrian Tivey,Martin Aslett,Arnaud Kerhornou,Alasdair Ivens,Audrey Fraser,Marie-Adèle Rajandream,Tim Carver,Halina Norbertczak,Tracey Chillingworth,Zahra Hance,Kay Jagels,Sharon Moule,Doug Ormond,Simon Rutter,Rob Squares,Sally Whitehead,Ester Rabbinowitsch,Claire Arrowsmith,Brian White,Scott Thurston,Frédéric Bringaud,Sandra L. Baldauf,Adam Faulconbridge,Daniel C. Jeffares,Daniel P. Depledge,Samuel O. Oyola,James D. Hilley,Loislene O. Brito,Luiz R. O. Tosi,Barclay G. Barrell,Angela K. Cruz,Jeremy C. Mottram,Deborah F. Smith,Matthew Berriman +41 more
TL;DR: It is shown that pseudogene formation and gene loss are the principal forces shaping the different genomes of Leishmania, and genes that are differentially distributed between the species encode proteins implicated in host-pathogen interactions and parasite survival in the macrophage.