O
Oliver J. Culley
Researcher at King's College London
Publications - 11
Citations - 660
Oliver J. Culley is an academic researcher from King's College London. The author has contributed to research in topics: Induced pluripotent stem cell & Wnt signaling pathway. The author has an hindex of 7, co-authored 11 publications receiving 488 citations.
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Common genetic variation drives molecular heterogeneity in human iPSCs
Helena Kilpinen,Angela Goncalves,Andreas Leha,Vackar Afzal,Kaur Alasoo,Sofie Ashford,Sendu Bala,Dalila Bensaddek,Francesco Paolo Casale,Oliver J. Culley,Petr Danacek,Adam Faulconbridge,Peter W. Harrison,Annie Kathuria,Davis J. McCarthy,Davis J. McCarthy,Shane A. McCarthy,Ruta Meleckyte,Yasin Memari,Nathalie Moens,Filipa A.C. Soares,Alice L. Mann,Ian Streeter,Chukwuma A. Agu,Alex Alderton,Rachel Nelson,Sarah Harper,Minal Patel,A. White,Sharad R. Patel,Laura Clarke,Reena Halai,Christopher M. Kirton,Anja Kolb-Kokocinski,Philip L. Beales,Ewan Birney,Davide Danovi,Angus I. Lamond,Willem H. Ouwehand,Willem H. Ouwehand,Willem H. Ouwehand,Ludovic Vallier,Ludovic Vallier,Fiona M. Watt,Richard Durbin,Oliver Stegle,Daniel J. Gaffney +46 more
TL;DR: This study outlines the major sources of genetic and phenotypic variation in iPS cells and establishes their suitability as models of complex human traits and cancer.
Journal ArticleDOI
Dermal Blimp1 Acts Downstream of Epidermal TGFβ and Wnt/β-Catenin to Regulate Hair Follicle Formation and Growth
Stephanie B. Telerman,Emanuel Rognoni,Inês Sequeira,Angela Oliveira Pisco,Beate M. Lichtenberger,Oliver J. Culley,Priyalakshmi Viswanathan,Ryan R. Driskell,Fiona M. Watt +8 more
TL;DR: The functional role of Blimp1 is revealed in promoting the dermal papilla inductive signaling cascade that initiates HF growth, including transforming growth factor-β and Wnt/β-catenin.
Journal ArticleDOI
A high-content platform to characterise human induced pluripotent stem cell lines.
Andreas Leha,Nathalie Moens,Ruta Meleckyte,Oliver J. Culley,Mia K. R. Gervasio,Maximilian Kerz,Andreas Reimer,Stuart A. Cain,Ian Streeter,Amos Folarin,Oliver Stegle,Cay M. Kielty,Richard Durbin,Fiona M. Watt,Davide Danovi +14 more
TL;DR: In this paper, a high-content platform for phenotypic analysis of human induced pluripotent stem cells (iPSC) lines is described, where cells are dissociated and seeded as single cells onto 96-well plates coated with fibronectin at three different concentrations.
Journal ArticleDOI
Identifying Extrinsic versus Intrinsic Drivers of Variation in Cell Behavior in Human iPSC Lines from Healthy Donors.
Alessandra Vigilante,Anna Laddach,Nathalie Moens,Ruta Meleckyte,Andreas Leha,Arsham Ghahramani,Oliver J. Culley,Annie Kathuria,Chloe Hurling,Alice Vickers,Erika Wiseman,Mukul Tewary,Peter W. Zandstra,Richard Durbin,Franca Fraternali,Oliver Stegle,Ewan Birney,Nicholas M. Luscombe,Davide Danovi,Fiona M. Watt +19 more
TL;DR: This study establishes a strategy for examining the genetic basis of inter-individual variability in cell behavior and identifies genes that correlate in expression with intrinsic and extrinsic PEER factors and associate outlier cell behavior with genes containing rare deleterious non-synonymous SNVs.
Journal ArticleDOI
Corrigendum: Common genetic variation drives molecular heterogeneity in human iPSCs
Helena Kilpinen,Angela Goncalves,Andreas Leha,Vackar Afzal,Kaur Alasoo,Sofie Ashford,Sendu Bala,Dalila Bensaddek,Francesco Paolo Casale,Oliver J. Culley,Petr Danecek,Adam Faulconbridge,Peter W. Harrison,Annie Kathuria,Davis J. McCarthy,Shane A. McCarthy,Ruta Meleckyte,Yasin Memari,Nathalie Moens,Filipa A.C. Soares,Alice L. Mann,Ian Streeter,Chukwuma A. Agu,Alex Alderton,Rachel Nelson,Sarah Harper,Minal Patel,A. White,Sharad R. Patel,Laura Clarke,Reena Halai,Christopher M. Kirton,Anja Kolb-Kokocinski,Philip L. Beales,Ewan Birney,Davide Danovi,Angus I. Lamond,Willem H. Ouwehand,Ludovic Vallier,Fiona M. Watt,Richard Durbin,Oliver Stegle,Daniel J. Gaffney +42 more
TL;DR: This corrects the article DOI: 10.1038/nature22403 to indicate that the author of the paper is a scientist rather than a scientist-in-residence, as previously reported.