Adam Kassan

TL;DR: Acyl-CoA synthetase 3 is recruited early to lipid droplet assembly sites on the ER, where it is required for efficient lipid droplets nucleation and lipid storage.

TL;DR: It is demonstrated that impaired proliferation and low survival with glucose restriction is a shortcoming of CAV1-deficient cells caused by impaired mitochondrial function, and it is confirmed that this mitochondrial dysfunction predisposes CAv1- deficient animals to mitochondrial-related diseases such as steatohepatitis and neurodegeneration.

TL;DR: Embryos with droplet-bound histones displayed more than a fourfold survival advantage when challenged with four different bacterial species, suggesting that this intracellular antibacterial defense system may function in adult flies, and also potentially in mice.

TL;DR: It is shown that targeting is a process cooperatively mediated by two motifs, and remarkable similarities with the signals that target proteins to the membrane of mitochondria and peroxisomes are uncovered.

TL;DR: It is demonstrated that lack of CAV1 alters hepatocyte energy metabolism homeostasis under physiological and pathological conditions.