Alba Fajardo

TL;DR: Acyl-CoA synthetase 3 is recruited early to lipid droplet assembly sites on the ER, where it is required for efficient lipid droplets nucleation and lipid storage.

TL;DR: The existence of a specialized cellular network connecting the cellular energetic status and MT dynamics to coordinate the functioning of LDs and mitochondria during nutrient scarcity is described.

TL;DR: It is shown that mammalian LDs are endowed with a protein-mediated antimicrobial capacity, which is up-regulated during polymicrobial sepsis and by LPS, and may potentially be advantageous for organizing an intracellular host defense.

TL;DR: It is demonstrated that impaired proliferation and low survival with glucose restriction is a shortcoming of CAV1-deficient cells caused by impaired mitochondrial function, and it is confirmed that this mitochondrial dysfunction predisposes CAv1- deficient animals to mitochondrial-related diseases such as steatohepatitis and neurodegeneration.

TL;DR: It is proposed that fat storage compartmentalization within a cell population is a protective social organization to reduce lipotoxicity and reduces the risk of lipot toxicity to the population without impairing overall lipid homeostasis.