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Adam Prahl
Researcher at University of Gdańsk
Publications - 75
Citations - 771
Adam Prahl is an academic researcher from University of Gdańsk. The author has contributed to research in topics: Bradykinin & Acylation. The author has an hindex of 13, co-authored 70 publications receiving 693 citations. Previous affiliations of Adam Prahl include National Institutes of Health & Academy of Sciences of the Czech Republic.
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Journal ArticleDOI
Reconstruction of the Conserved β-Bulge in Mammalian Defensins Using d-Amino Acids
Cao Xie,Cao Xie,Adam Prahl,Bryan Ericksen,Zhibin Wu,Pengyun Zeng,Xiangqun Li,Weiyue Lu,Jacek Lubkowski,Wuyuan Lu +9 more
TL;DR: A conformational prerequisite in the β-bulge of defensin essential for correct folding and native structure is identified, thereby explaining the molecular basis of the Gly-Xaa-Cys motif conserved in all mammalian defensins.
Journal ArticleDOI
Studies of the Biological Properties of Human beta-Defensin 1.
TL;DR: It is found that cationic residues located near the C terminus of hBD1 define most of the anti-E.
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The Multi-Leu Peptide Inhibitor Discriminates Between PACE4 and Furin And Exhibits Antiproliferative Effects On Prostate Cancer Cells
Christine Levesque,Martin Fugère,Anna Kwiatkowska,Frédéric Couture,Roxane Desjardins,Sophie Routhier,Philippe Moussette,Adam Prahl,Bernard Lammek,Jon R. Appel,Richard A. Houghten,François D'Anjou,Yves L. Dory,Witold Neugebauer,Robert Day +14 more
TL;DR: It is concluded that peptide-based inhibitors can yield specific PC inhibitors and that the ML-peptide is an important lead compound that could potentially have applications in prostate cancer.
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From pro defensins to defensins: synthesis and characterization of human neutrophil pro alpha-defensin-1 and its mature domain.
TL;DR: Total chemical synthesis of the 75-residue human neutrophil pro alpha-defensin-1 (proHNP1) via native chemical ligation is described, confirming the mode of intramolecular inactivation of human alpha- defensin precursors.
Journal ArticleDOI
Design, Synthesis, and Structure−Activity Relationship Studies of a Potent PACE4 Inhibitor
Anna Kwiatkowska,Frédéric Couture,Christine Levesque,Kévin Ly,Roxane Desjardins,Sophie Beauchemin,Adam Prahl,Bernard Lammek,Witold Neugebauer,Yves L. Dory,Robert Day +10 more
TL;DR: The design and synthesis of a novel, potent, and relatively selective PACE4 inhibitor known as a Multi-Leu (ML) peptide is reported, with analogues with an improved stability profile and excellent antiproliferative properties.