A
Adrian Rothenfluh
Researcher at University of Utah
Publications - 59
Citations - 4046
Adrian Rothenfluh is an academic researcher from University of Utah. The author has contributed to research in topics: Biology & Timeless. The author has an hindex of 21, co-authored 51 publications receiving 3697 citations. Previous affiliations of Adrian Rothenfluh include University of Texas at Dallas & University of California, San Francisco.
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Journal ArticleDOI
double-time Is a Novel Drosophila Clock Gene that Regulates PERIOD Protein Accumulation
TL;DR: It is proposed that the normal function of DOUBLETIME protein is to reduce the stability and thus the level of accumulation of monomeric PER proteins, which would promote a delay between per/tim transcription and PER/TIM complex function, which is essential for molecular rhythmicity.
Journal ArticleDOI
Guidelines on nicotine dose selection for in vivo research
Shannon G. Matta,David J.K. Balfour,Neal L. Benowitz,R. Thomas Boyd,Jerry J. Buccafusco,Anthony R. Caggiula,Caroline R. Craig,Allan C. Collins,M. Imad Damaj,Eric C. Donny,Phillip S. Gardiner,Sharon R. Grady,Ulrike Heberlein,Sherry Leonard,Edward D. Levin,Ronald J. Lukas,Athina Markou,Michael J. Marks,Sarah E. McCallum,Neeraja Parameswaran,Kenneth A. Perkins,Marina R. Picciotto,Maryka Quik,Jed E. Rose,Adrian Rothenfluh,William R Schafer,Ian P. Stolerman,Rachel F. Tyndale,Jeanne M. Wehner,Jeffrey M. Zirger +29 more
TL;DR: A new, experimentally based compilation of species-specific dose selection for studies on the in vivo effects of nicotine, addressing issues related to genetic background, age, acute vs chronic exposure, route of administration, and behavioral responses is provided.
Journal ArticleDOI
The Drosophila Clock Gene double-time Encodes a Protein Closely Related to Human Casein Kinase Iε
Brian Kloss,Jeffrey L. Price,Lino Saez,Justin Blau,Adrian Rothenfluh,Cedric S. Wesley,Michael W. Young +6 more
TL;DR: DBT is capable of binding to PER in vitro and in Drosophila cells, suggesting that a physical association of PER and DBT regulates PER phosphorylation and accumulation in vivo.
Journal ArticleDOI
Phosphorylation of PERIOD Is Influenced by Cycling Physical Associations of DOUBLE-TIME, PERIOD, and TIMELESS in the Drosophila Clock
TL;DR: The varying associations of PER, DBT and TIM appear to determine the onset and duration of nuclear PER function within the Drosophila clock.
Journal ArticleDOI
A TIMELESS-Independent Function for PERIOD Proteins in the Drosophila Clock
TL;DR: In the absence of TIM, nuclear PER can function as a potent negative transcriptional regulator and Conversion of PER/TIM heterodimers to nuclear PER proteins appears to be required to complete transcriptional repression and terminate each circadian molecular cycle.