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Agnès Delaunay-Moisan
Researcher at Université Paris-Saclay
Publications - 24
Citations - 1054
Agnès Delaunay-Moisan is an academic researcher from Université Paris-Saclay. The author has contributed to research in topics: Endoplasmic reticulum & Glutathione. The author has an hindex of 13, co-authored 21 publications receiving 789 citations. Previous affiliations of Agnès Delaunay-Moisan include Commissariat à l'énergie atomique et aux énergies alternatives.
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Journal ArticleDOI
Glutathione revisited: a vital function in iron metabolism and ancillary role in thiol-redox control.
Chitranshu Kumar,Aeid Igbaria,Benoît D'Autréaux,Anne-Gaëlle Planson,Christophe Junot,Emmanuel Godat,Anand K. Bachhawat,Agnès Delaunay-Moisan,Michel B. Toledano +8 more
TL;DR: It is proposed that glutathione is essential by its requirement in ISC assembly, but only serves as a thioredoxin backup in cytosolic thiol‐redox maintenance, a model challenging the traditional view of it as prime actor in thiol-redox control.
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Functions and cellular compartmentation of the thioredoxin and glutathione pathways in yeast
TL;DR: Identifying the mechanisms regulating fluxes of GSH and oxidized glutathione between cytosol and ER, IMS, and possibly also peroxisomes, vacuole is needed to establish the proposed model of eukaryotic thiol-redox homeostasis, which should facilitate exploration of this system in mammals and plants.
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Physiologically relevant reconstitution of iron-sulfur cluster biosynthesis uncovers persulfide-processing functions of ferredoxin-2 and frataxin.
Sylvain Gervason,Djabir Larkem,Amir Ben Mansour,Thomas Botzanowski,Christina S. Müller,Ludovic Pecqueur,Gwenaelle Le Pavec,Agnès Delaunay-Moisan,Omar Brun,Jordi Agramunt,Anna Grandas,Marc Fontecave,Volker Schünemann,Sarah Cianférani,Christina Sizun,Michel B. Toledano,Benoît D'Autréaux +16 more
TL;DR: It is proposed that this reconstitution recapitulates physiological conditions which provides a model for Fe-S cluster biosynthesis, clarifies the roles of FDX2 and FXN and may help develop Friedreich’s ataxia therapies.
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Endoplasmic Reticulum Transport of Glutathione by Sec61 Is Regulated by Ero1 and Bip.
Alise J. Ponsero,Aeid Igbaria,Maxwell A. Darch,Samia Miled,Caryn E. Outten,Jakob R. Winther,Gael Palais,Benoît D'Autréaux,Agnès Delaunay-Moisan,Michel B. Toledano +9 more
TL;DR: The ER redox poise is tuned by reciprocal control of glutathione import and Ero1 activation, and the ER protein-conducting channel is permeable to small molecules, provided the driving force of a concentration gradient.
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The antioxidant machinery of the endoplasmic reticulum: Protection and signaling
TL;DR: This review focuses on H2O2-antioxidant cross talk in the endoplasmic reticulum (ER), which is intimately linked to the process of oxidative protein folding and may set a basis for establishing ER redox processes as a major line of future signaling research.