A
Afsar U. Ahmed
Researcher at Hudson Institute of Medical Research
Publications - 21
Citations - 1515
Afsar U. Ahmed is an academic researcher from Hudson Institute of Medical Research. The author has contributed to research in topics: Signal transduction & Integrin-linked kinase. The author has an hindex of 11, co-authored 17 publications receiving 1332 citations. Previous affiliations of Afsar U. Ahmed include La Trobe University & Monash Medical Centre.
Papers
More filters
Journal ArticleDOI
IAP Antagonists Target cIAP1 to Induce TNFα-Dependent Apoptosis
James E Vince,W. Wei-Lynn Wong,Nufail Khan,Rebecca Feltham,Diep Chau,Afsar U. Ahmed,Christopher A. Benetatos,Srinivas K. Chunduru,Stephen M. Condon,Mark A. McKinlay,Robert Brink,Martin Leverkus,Vinay Tergaonkar,Pascal Schneider,Bernard A. Callus,Frank Koentgen,David L. Vaux,John Silke +17 more
TL;DR: It is shown that apoptosis caused by an IAC is blocked by the caspase 8 inhibitor crmA and that IAP antagonists activate NF-κB signaling via inhibtion of cIAP1.
Journal ArticleDOI
An overview of inflammation: mechanism and consequences
TL;DR: Alterations in inflammatory responses due to persistent inducers or genetic variations are on the rise over the last couple of decades, causing a variety of inflammatory diseases and pathophysiological conditions.
Journal ArticleDOI
Diverse Cytopathologies in Mitochondrial Disease Are Caused by AMP-activated Protein Kinase Signaling
Paul B. Bokko,Lisa M. Francione,Esther Bandala-Sanchez,Afsar U. Ahmed,Sarah J. Annesley,Xiuli Huang,Taruna Khurana,Alan R. Kimmel,Paul R. Fisher +8 more
TL;DR: The results show that diverse cytopathologies in Dictyostelium mitochondrial disease are caused by chronic AMPK signaling not by insufficient ATP.
Journal ArticleDOI
Integrin-linked Kinase Modulates Lipopolysaccharide- and Helicobacter pylori-induced Nuclear Factor κB-activated Tumor Necrosis Factor-α Production via Regulation of p65 Serine 536 Phosphorylation
Afsar U. Ahmed,Soroush T. Sarvestani,Michael P. Gantier,Bryan R.G. Williams,Gregory Hannigan +4 more
TL;DR: It is shown that ILK mediates pro-inflammatory signaling in response to lipopolysaccharide (LPS), implicate ILK as a critical regulatory molecule for the NF-κB-mediated pro- inflammatory signaling pathway, which is essential for innate immune responses against pathogenic microorganisms.
Journal ArticleDOI
Transcriptional Activation of Inflammatory Genes: Mechanistic Insight into Selectivity and Diversity.
TL;DR: Among a number of transcription factors identified to date, NF-κB still remains the most prominent and studied factor for its diverse range of selective transcriptional activities.