M
Michael P. Gantier
Researcher at Hudson Institute of Medical Research
Publications - 80
Citations - 4432
Michael P. Gantier is an academic researcher from Hudson Institute of Medical Research. The author has contributed to research in topics: Innate immune system & RNA interference. The author has an hindex of 31, co-authored 72 publications receiving 3376 citations. Previous affiliations of Michael P. Gantier include Monash Institute of Medical Research & University College Dublin.
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Journal ArticleDOI
Analysis of microRNA turnover in mammalian cells following Dicer1 ablation
Michael P. Gantier,Claire E. McCoy,Irina Rusinova,Damien Saulep,Die Wang,Dakang Xu,Aaron T. Irving,Mark A. Behlke,Paul J. Hertzog,Fabienne Mackay,Bryan R.G. Williams +10 more
TL;DR: It is indicated that miRNAs are up to 10× more stable than messenger RNA and support the existence of novel mechanism(s) controlling selective miRNA cellular concentration and function.
Journal ArticleDOI
TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS
Chien-Hsiung Yu,Chien-Hsiung Yu,Sophia Davidson,Sophia Davidson,Cassandra R. Harapas,Cassandra R. Harapas,James B. Hilton,James B. Hilton,Michael J. Mlodzianoski,Michael J. Mlodzianoski,Pawat Laohamonthonkul,Pawat Laohamonthonkul,Cynthia Louis,Cynthia Louis,Ronnie Ren Jie Low,Ronnie Ren Jie Low,Jonas Moecking,Jonas Moecking,Jonas Moecking,Dominic De Nardo,Dominic De Nardo,Dominic De Nardo,Katherine R. Balka,Katherine R. Balka,Katherine R. Balka,Dale J. Calleja,Dale J. Calleja,Fiona Moghaddas,Fiona Moghaddas,Fiona Moghaddas,Erya Ni,Erya Ni,Catriona McLean,Andre L. Samson,Andre L. Samson,Shiraz Tyebji,Shiraz Tyebji,Christopher J. Tonkin,Christopher J. Tonkin,Christopher R. Bye,Bradley J. Turner,Genevieve Pepin,Genevieve Pepin,Michael P. Gantier,Michael P. Gantier,Kelly L. Rogers,Kelly L. Rogers,Kate McArthur,Peter J. Crouch,Peter J. Crouch,Seth L. Masters,Seth L. Masters +51 more
TL;DR: The results identify mtDNA release and cGAS/STING activation as critical determinants of TDP-43-associated pathology and demonstrate the potential for targeting this pathway in ALS.
Journal ArticleDOI
IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction
Claudia A. Nold-Petry,Camden Lo,Ina Rudloff,Kirstin Elgass,Suzhao Li,Michael P. Gantier,Amelie S. Lotz-Havla,Søren W. Gersting,Steven X. Cho,Jason C. Lao,Andrew M. Ellisdon,Björn Rotter,Tania Azam,Niamh E. Mangan,Fernando J. Rossello,James C. Whisstock,Philip Bufler,Cecilia Garlanda,Alberto Mantovani,Charles A. Dinarello,Marcel F. Nold +20 more
TL;DR: Nold et al. as mentioned in this paper identified the receptor for IL-37 and clarified the molecular nature of the anti-inflammatory pathway induced by this cytokine, which is a member of the IL-1 family.
Journal ArticleDOI
The response of mammalian cells to double-stranded RNA.
TL;DR: An overview of the current knowledge of dsRNA-mediated pathways in mammalian cells is presented and a link between these pathways and application of RNAi is introduced.
Journal Article
IL-37 requires the receptors IL-18Ra and IL-1R8 (SIGIRR) to carry out its multi-faceted anti-inflammatory program on innate signal transduction
C. Nold,C. Lo,I Rudloff,K. Elgass,Suzhao Li,Michael P. Gantier,A. Lotz-Hayla,S. Gersting,S. Cho,J. Lao,A. Ellisdon,B. Rotter,T. Azam,Niamh E. Mangan,F. Rosello,J. Whisstock,Philip Bufler,Cecilia Garlanda,Alberto Mantovani,Charles A. Dinarello,Marcel F. Nold +20 more
TL;DR: Proteomic and transcriptomic investigations revealed that IL-37 used IL-1R8 to harness the anti-inflammatory properties of the signaling molecules Mer, PTEN, STAT3 and p62(dok) and to inhibit the kinases Fyn and TAK1 and the transcription factor NF-κB, as well as mitogen-activated protein kinases.