A
Ahmed Ashour
Researcher at Mansoura University
Publications - 74
Citations - 987
Ahmed Ashour is an academic researcher from Mansoura University. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 15, co-authored 46 publications receiving 624 citations. Previous affiliations of Ahmed Ashour include University of Alabama & University of Texas MD Anderson Cancer Center.
Papers
More filters
Journal ArticleDOI
Targeting elongation factor-2 kinase (eEF-2K) induces apoptosis in human pancreatic cancer cells.
Ahmed Ashour,Ahmed Ashour,Abdel Aziz H. Abdel-Aziz,Ahmed M. Mansour,S. Neslihan Alpay,Longfei Huo,Bulent Ozpolat +6 more
TL;DR: It is shown, for the first time, that the down-regulation of eEF-2K leads to induction of intrinsic, extrinsic as well as AIF-dependent apoptosis in PaCa cells, suggesting that eEF -2K may represent an attractive therapeutic target for the future anticancer agents in Pa Ca.
Journal ArticleDOI
FOXM1 regulates expression of eukaryotic elongation factor 2 kinase and promotes proliferation, invasion and tumorgenesis of human triple negative breast cancer cells.
TL;DR: This study provides the first evidence about the transcriptional regulation of eEF2K in TNBC and the role ofFOXM1 in mediating breast cancer cell proliferation, survival, migration/invasion, progression and tumorgenesis and highlighting the potential of FOXM1/e EF2K axis as a molecular target in breast and other cancers.
Journal ArticleDOI
Calendulaglycoside A Showing Potential Activity Against SARS-CoV-2 Main Protease: Molecular Docking, Molecular Dynamics, and SAR Studies.
Thomas Schleicher,Ahmed A. Zaki,Ahmed Ashour,Sameh S. Elhady,Khaled M. Darwish,Ahmed A. Al-Karmalawy +5 more
TL;DR: A promising SAR is clarified responsible for the antiviral activity against the SARS-CoV-2 Mpro and the design of new drug candidates targeting it as well is clarified and could be promising for fast examining the previously isolated triterpenes both pre-clinically and clinically for the treatment of COVID-19.
Journal ArticleDOI
Elongation factor‐2 kinase regulates TG2/β1 integrin/Src/uPAR pathway and epithelial–mesenchymal transition mediating pancreatic cancer cells invasion
Ahmed Ashour,Ahmed Ashour,Nilgun Gurbuz,Sultan Neslihan Alpay,Abdel Aziz H. Abdel-Aziz,Ahmed M. Mansour,Longfei Huo,Bulent Ozpolat +7 more
TL;DR: Results show, for the first time, that eEF‐2K is involved in regulation of the invasive phenotype of PaCa cells through promoting a new signalling pathway, which is mediated by TG2/β1 integrin/Src/uPAR/MMP‐2, and the induction of EMT biomarkers which enhance cancer cell motility and metastatic potential.
Journal ArticleDOI
Molecular docking reveals the potential of: Cleome amblyocarpa isolated compounds to inhibit COVID-19 virus main protease
TL;DR: The explanation of the SAR required for targeting the newly emerged SARS-CoV-2 protease is explained and facilitates the future design and synthesis of new drugs targeting it as well.