Showing papers in "Journal of Traditional and Complementary Medicine in 2021"

TL;DR: A promising SAR is clarified responsible for the antiviral activity against the SARS-CoV-2 Mpro and the design of new drug candidates targeting it as well is clarified and could be promising for fast examining the previously isolated triterpenes both pre-clinically and clinically for the treatment of COVID-19.

TL;DR: In this article, the authors conducted molecular docking and structural dynamics studies with a set of 65 tea bioactive compounds to illustrate their ability to inhibit NSP16 of SARS-CoV-2.

TL;DR: This study explores natural products isolated from edible and medicinal mushrooms that have been reported to possess anti-HIV protease and highlights the potential of existing mushroom-derived natural compounds to be used to fight against SARS-CoV-2 infection.

TL;DR: In this article, the role of rutin in the inhibition of essential proteins of SARS-CoV-2 including main protease, RNA-dependent RNA polymerase (RdRp), papain-like protease (PLpro), and spike (S)-protein through different in silico approaches.

TL;DR: In this paper, a comprehensive review of plant-and mushroom-derived compounds relevant to mechanistic targets involved in SARS-CoV-2 infection and inflammatory-associated pathogenesis, including viral entry, replication and release, and the renin-angiotensin-aldosterone system (RAAS), is presented.

TL;DR: M. spicata essential oil with main component of carvone has potency for treatment of flatulence related to indigestion, cesarean section and Dysmenorrhea and can reduce the pain severity during the colonoscopy or dysmenorrheal conditions.

TL;DR: It can be concluded that I. obliquus fits the definition of functional food and has a potentially positive effect on health beyond basic nutrition; however, studies that meet the evidence-based medicine (EBM) criteria are needed.

TL;DR: In this article, a molecular docking study was performed to search potential phytochemicals and drugs that can block the entry of SARS-CoV-2 into host cells by inhibiting the proteolytic cleavage activity of furin and TMPRSS2.

TL;DR: Huashi Baidu Decoction (HSBD) is a novel complex prescription which has positive effects on severe COVID-19 through integrating network pharmacological methods as discussed by the authors.

TL;DR: It is revealed that Nymphaea lotus possesses anti-nociceptive activities which may be mediated via the opioidergic system as well as mild anti-inflammatory activities thus providing scientific basis for the use of the plant in the management of pain and inflammatory diseases.

TL;DR: It has been shown that Portuguese heather (Erica cinereal) honey presented the most similar physicochemical properties to manuka honey (specially phenolic and flavonoids contents) and can also act as a good Candida species biofilm reducer, namely for C. tropicalis.

TL;DR: Collective data suggest that A.reticulata leaf extract may have a stimulatory effect in diabetic wound healing.

TL;DR: dMF should supplement the switch to nutrient-rich from current energy-dense diets that are progressively crippling national health systems and outcomes should be holistic commensurate with the constellation of disease risks.

TL;DR: The information on human pharmacokinetics of AL, when given as capsule formulation of the standardized extract, would assist in further dose optimization in cholangiocarcinoma patients with the defined pharmacokinetic-pharmacodynamic relationship.

TL;DR: Olive leaves extract of Tanta was selected as the most active agent against Methicillin-resistant S. aureus and checkerboard dilution technique approved that the interaction between Tanta LEM crude extract and Ciprofloxacin was synergistic.

TL;DR: Clinical study proved the superior anti-skin aging efficacy of amla branch, including the lightening skin color, the enhanced skin elasticity and hydration, and the skin wrinkle reduction.

TL;DR: Results obtained suggests that Artemisia herbs-alba aqueous extract supplementation reduces alloxan-induced free radical generation, potentiates the antioxidant defense system and alleviates renal sensitivity to oxidative stress.

TL;DR: Wang et al. as discussed by the authors examined the inhibitory effects of two lignans (honokiol and magnolol) on furin-like enzymatic activity using a fluorogenic substrate with whole-cell lysates.

TL;DR: Findings provide ample evidence to validate the traditional use of A. polycarpa in the management of DM and act by restoring pancreatic beta-cell integrity through mopping of reactive oxygen species (ROS) associated with the diabetic state, and thereby improving pancreatic function and consequently, the lowering of FBG levels.

TL;DR: Mm(Lour.) water fraction in CMC Na gelling agent provided an option to be developed as a topical drug on diabetic wound healing treatment, showed by enhancement of collagen synthesis and angiogenesis.

TL;DR: In this paper, a multi-level rigorous screening of 47 medicinal plant-based phytochemicals for discovering effective phytochemical inhibitors against the host and viral targets was performed.

TL;DR: Recoveries of parameters suggest that the bioactive factors present in the extracts of Bacopa monnieri offer neuroprotection by interrupting the pathological cascade that occurs during epileptogenesis.

TL;DR: The obtained results supported the antidepressant-like and anxiolytic-like effects of ethanol extract of T.chebula in mice and explored the effects of extract on monoamine oxidase –A levels in mouse brain.

TL;DR: In this paper, natural products capable of interfering with SARS-CoV-2 cellular infection and replication through their action on autophagy have been reported as adjuvant therapeutics for the management of COVID-19 pandemic.

TL;DR: For the first time this study revealed that eugenol can be considered as a potential candidate for managing the functional disabilities associated with TBI because of its antioxidant activities.

TL;DR: Yang-Qi deficiency is associated with clinically significant fatigue in breast cancer patients, and the association of Phlegm-Stasis syndrome and fatigue as disease duration increases cannot be ignored.

TL;DR: In this paper, a structure-based virtual screening was performed using the AutoDock Vina program within PyRX software, the binding affinities of compounds were verified using isothermal titration calorimetry (ITC), the inhibitions of SARS-CoV-2 viral infection efficacy were examined by lentivirus particles pseudotyped (Vpp) infection assay, and the cell viability was tested by 293T cell in MTT assay.

TL;DR: The difference between lagged HRA responses on Yoga in comparison with other groups can be an emphasis on the importance of choosing the type of meditation technique and its effects on the cardiovascular system.

TL;DR: In this paper, the effect of mindfulness-based stress reduction (MBSR) on the optic disc perfusion of patients with primary open angle glaucoma (POAG) was assessed.

TL;DR: A review of the available information, summarizes current research related to the gut-microbiota-heart axis, enumerates the foods and herbs that are CVD-risk precursors, and illustrates how metabolites become CVD risk factors through the metabolism of gut microbiota as mentioned in this paper.