Aida Botelho de Sousa

TL;DR: QUAZAR AML-001 (NCT01757535), a phase III international, randomized, double-blind, placebo (PBO)-controlled study evaluating CC-486 as maintenance therapy in pts aged ≥55 years with AML in first remission following IC, demonstrated significant improvements in OS and RFS.

TL;DR: It is found that adult B-cell acute lymphoblastic leukemia samples show significantly higher CK2 kinase activity and lower PTEN lipid phosphatase activity than healthy controls, and it is suggested that CK2 inhibition may constitute a valid, novel therapeutic tool in this malignancy.

TL;DR: In this series treatment success was related to its rapid onset and to the recovery of neutropenia, and fungal infections are responsible for death in a significant number of patients.

TL;DR: Philadelphia chromosome (Ph1), which results from the reciprocal translocation t(9;22)(q34;q11), is the hallmark of almost all the cases of chronic myeloid leukemia (CML).

TL;DR: BAL GM and PCR sampling aids in IA diagnosis but needs further validation studies to differentiate between colonization and true infection in cases where serum GM or PCR are negative.