J
João F. Lacerda
Researcher at Instituto de Medicina Molecular
Publications - 64
Citations - 2078
João F. Lacerda is an academic researcher from Instituto de Medicina Molecular. The author has contributed to research in topics: Transplantation & Hematopoietic stem cell transplantation. The author has an hindex of 21, co-authored 53 publications receiving 1730 citations. Previous affiliations of João F. Lacerda include University of Lisbon & Memorial Sloan Kettering Cancer Center.
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Journal ArticleDOI
Genetic PTX3 Deficiency and Aspergillosis in Stem-Cell Transplantation
Cristina Cunha,Franco Aversa,João F. Lacerda,Alessandro Busca,Oliver Kurzai,Matthias Grube,Jürgen Löffler,Johan Maertens,Alain S. Bell,Antonio Inforzato,Elisa Barbati,Bruno Almeida,Pedro Santos e Sousa,Anna Maria Barbui,Leonardo Potenza,Morena Caira,Fernando Rodrigues,Giovanni Salvatori,Livio Pagano,Mario Luppi,Alberto Mantovani,Andrea Velardi,Luigina Romani,Agostinho Carvalho +23 more
TL;DR: Genetic deficiency of PTX3 affects the antifungal capacity of neutrophils and may contribute to the risk of invasive aspergillosis in patients treated with HSCT.
Journal ArticleDOI
A survey of fully haploidentical hematopoietic stem cell transplantation in adults with high-risk acute leukemia: a risk factor analysis of outcomes for patients in remission at transplantation
Fabio Ciceri,Myriam Labopin,Franco Aversa,Jakob M. Rowe,Donald Bunjes,Philippe Lewalle,Arnon Nagler,Paolo Bartolomeo,João F. Lacerda,Maria Teresa Lupo Stanghellini,Emmanuelle Polge,Francesco Frassoni,Massimo F. Martelli,Vanderson Rocha +13 more
TL;DR: Haploidentical hematopoietic stem cell transplantation can be an alternative option for the treatment of high-risk acute leukemia patients in remission, lacking a human leukocyte antigen-matched donor.
Journal ArticleDOI
Biology and adoptive cell therapy of Epstein-Barr virus-associated lymphoproliferative disorders in recipients of marrow allografts
Richard J. O'Reilly,Trudy N. Small,Esperanza B. Papadopoulos,Kenneth G. Lucas,João F. Lacerda,Lydia Koulova +5 more
TL;DR: A review of the biology and immunology of EBV infection in the normal host, the features of donor, host and virus which contribute to the development of Epstein-Barr virus (EBV)-associated lymphoproliferative diseases and the mechanisms whereby they are controlled by adoptive transfer of immune T cells is presented in this paper.
Journal ArticleDOI
Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus
Mark H. T. Stappers,Alexandra E. Clark,Vishukumar Aimanianda,Stefan Bidula,Delyth M. Reid,Patawee Asamaphan,Sarah E. Hardison,Ivy M. Dambuza,Isabel Valsecchi,Bernhard Kerscher,Anthony Plato,Carol Wallace,Raif Yuecel,Betty Hebecker,Maria da Glória Teixeira de Sousa,Cristina Cunha,Yan Liu,Ten Feizi,Axel A. Brakhage,Kyung J. Kwon-Chung,Neil A. R. Gow,Matteo Zanda,Monica Piras,Chiara Zanato,Martin Jaeger,Mihai G. Netea,Frank L. van de Veerdonk,João F. Lacerda,António Campos,Agostinho Carvalho,Janet A. Willment,Jean-Paul Latgé,Gordon D. Brown +32 more
TL;DR: A single nucleotide polymorphism of this receptor is identified that negatively affected myeloid inflammatory responses and significantly increased the susceptibility of stem-cell transplant recipients to disseminated Aspergillus infections.
Journal ArticleDOI
Unbalanced recovery of regulatory and effector T cells after allogeneic stem cell transplantation contributes to chronic GVHD
Ana C. Alho,Ana C. Alho,Haesook T. Kim,Marie J Chammas,Carol Reynolds,Tiago R. Matos,Edouard Forcade,Jennifer Whangbo,Sarah Nikiforow,Corey Cutler,John Koreth,Vincent T. Ho,Philippe Armand,Joseph H. Antin,Edwin P. Alyea,João F. Lacerda,Robert J. Soiffer,Jerome Ritz +17 more
TL;DR: These dynamic imbalances favor the production, expansion, and persistence of effector T cells over CD4Tregs over CD8 T cells and were associated with the development of chronic GVHD.