Ana Serra-Caetano

TL;DR: IgH isotypes from different IGHC gene blocks show different patterns, probably reflecting consecutive cycles of IgH isotype switch recombination through life, and maximum plasma levels were reached after PC and MBC counts peaked.

TL;DR: Evidence that IL-7 exerts a preferential proliferative effect on CD31(+) naive CD4(+) T cells from adult peripheral blood compared with theCD31(-) subset is provided and it is suggested that during adulthood CD31 (+) naive T cells are maintained by IL-6 and thatIL-7-based therapies may exert a preferential effect on this population.

TL;DR: It is found that adult B-cell acute lymphoblastic leukemia samples show significantly higher CK2 kinase activity and lower PTEN lipid phosphatase activity than healthy controls, and it is suggested that CK2 inhibition may constitute a valid, novel therapeutic tool in this malignancy.

TL;DR: Investigation of patients with PADs for the distribution of 41 blood B-cell and plasma cell (PC) subsets, including subsets defined by expression of distinct immunoglobulin heavy chain subclasses identified distinct PAD defective B- cell patterns that are associated with unique clinical profiles.

TL;DR: It is shown that by pulsing cells with EdU for incremental periods of time maximal EdU-coupled fluorescence is reached when pulsing times match the length of S phase, and these parameters can be estimated within a time frame that is shorter than a full cell cycle.