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Aiying Wang
Researcher at Chinese Academy of Sciences
Publications - 269
Citations - 6379
Aiying Wang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Amorphous carbon & Coating. The author has an hindex of 33, co-authored 238 publications receiving 4945 citations. Previous affiliations of Aiying Wang include Bristol-Myers Squibb & Xi'an Jiaotong University.
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Journal ArticleDOI
Discovery and Preclinical Profile of Saxagliptin (BMS-477118): A Highly Potent, Long-Acting, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes
David J. Augeri,Jeffrey A. Robl,David A. Betebenner,David R. Magnin,Ashish Khanna,James G. Robertson,Aiying Wang,Ligaya M. Simpkins,Prakash Taunk,Qi Huang,Songping Han,B.E. Abboa-Offei,Michael Cap,Li Xin,Li Tao,Effie Tozzo,Gustav E Welzel,Donald Egan,Jovita Marcinkeviciene,Shu Y Chang,Scott A. Biller,Mark S. Kirby,Rex A. Parker,Lawrence G. Hamann +23 more
TL;DR: Extension of this approach to adamantylglycine-derived inhibitors led to the discovery of highly potent inhibitors, including hydroxyadamantyl compound BMS-477118 (saxagliptin), a highly efficacious, stable, and long-acting DPP-IV inhibitor, which is currently undergoing clinical trials for treatment of type 2 diabetes.
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Discovery of Dapagliflozin: A Potent, Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitor for the Treatment of Type 2 Diabetes
Wei Meng,Bruce A. Ellsworth,Alexandra A. Nirschl,P.J. McCann,Manorama Patel,Ravindar N. Girotra,Gang Wu,Philip M. Sher,Eamonn P. Morrison,Scott A. Biller,Robert Zahler,Prashant P. Deshpande,Annie Pullockaran,Deborah Hagan,Nathan Morgan,Joseph R. Taylor,Mary T. Obermeier,William G. Humphreys,Ashish Khanna,Lorell Discenza,James G. Robertson,Aiying Wang,Songping Han,John R. Wetterau,Evan B. Janovitz,Oliver P. Flint,Jean M. Whaley,William N. Washburn +27 more
TL;DR: The C-aryl glucoside 6 (dapagliflozin) was identified as a potent and selective hSGLT2 inhibitor which reduced blood glucose levels in a dose-dependent manner by as much as 55% in hyperglycemic streptozotocin (STZ) rats.
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Structure and mechanical properties of W incorporated diamond-like carbon films prepared by a hybrid ion beam deposition technique
TL;DR: In this paper, diamond-like carbon films were prepared on silicon wafers using a hybrid deposition system composed of an end-Hall-type hydrocarbon ion gun and a tungsten DC magnetron sputter source.
Journal ArticleDOI
Nonvolatile resistive switching memory based on amorphous carbon
TL;DR: In this paper, Zhao et al. observed nonvolatile resistance memory behaviors in metal/a-C:H/Pt structures with device yield 90%, ON/OFF ratio >100, and retention time >105.
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Stem hydraulic traits and leaf water-stress tolerance are co-ordinated with the leaf phenology of angiosperm trees in an Asian tropical dry karst forest.
Pei-Li Fu,Yan-Juan Jiang,Yan-Juan Jiang,Aiying Wang,Timothy J. Brodribb,Jiao-Lin Zhang,Shi-Dan Zhu,Shi-Dan Zhu,Kun-Fang Cao +8 more
TL;DR: In this paper, a comparison was made of stem hydraulic conductivity, vulnerability curves, wood anatomy, leaf life span, leaf pressure volume characteristics and photosynthetic capacity of six evergreen and six deciduous tree species co-occurring in a tropical dry karst forest in south-west China.