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Ajay Macharouthu
Researcher at NHS Ayrshire and Arran
Publications - 9
Citations - 1065
Ajay Macharouthu is an academic researcher from NHS Ayrshire and Arran. The author has contributed to research in topics: Randomized controlled trial & Donepezil. The author has an hindex of 7, co-authored 9 publications receiving 881 citations. Previous affiliations of Ajay Macharouthu include University Hospital Crosshouse & Crichton Royal Hospital.
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Journal ArticleDOI
Donepezil and memantine for moderate-to-severe Alzheimer's disease.
Robert Howard,Rupert McShane,James Lindesay,Craig W. Ritchie,Ashley Baldwin,Robert Barber,Alistair Burns,Tom Dening,David Findlay,Clive Holmes,Alan Hughes,Robin Jacoby,Robert G. Jones,Roy W. Jones,Ian G. McKeith,Ajay Macharouthu,John T. O'Brien,Peter Passmore,Bart Sheehan,Edmund Juszczak,Cornelius Katona,Robert Kerrin Hills,Martin Knapp,Clive Ballard,Richard G. Brown,Sube Banerjee,Caroline Onions,Mary Griffin,Jessica Adams,Richard Gray,Tony Johnson,Peter Bentham,Patrick P. J. Phillips +32 more
TL;DR: In patients with moderate or severe Alzheimer's disease, continued treatment with donepezil was associated with cognitive benefits that exceeded the minimum clinically important difference and with significant functional benefits over the course of 12 months.
Journal ArticleDOI
Determining the minimum clinically important differences for outcomes in the DOMINO trial
Robert Howard,Patrick P. J. Phillips,Tony Johnson,John T. O'Brien,Bart Sheehan,James Lindesay,Peter Bentham,Alistair Burns,Clive Ballard,Clive Holmes,Ian G. McKeith,Robert Barber,Tom Dening,Craig W. Ritchie,Robert Jones,Ashley Baldwin,Peter Passmore,David Findlay,Alan Hughes,Ajay Macharouthu,Ajay Macharouthu,Sube Banerjee,Roy W. Jones,Martin Knapp,Richard G. Brown,Robin Jacoby,Jessica Adams,Mary Griffin,Richard Gray +28 more
TL;DR: Although less likely to be reported in clinical trials than expressions of the statistical significance of differences in outcomes, whether or not a treatment has delivered a specified minimum clinically important difference (MCID) is also relevant to patients and their caregivers and doctors.
Journal ArticleDOI
Nursing home placement in the Donepezil and Memantine in Moderate to Severe Alzheimer's Disease (DOMINO-AD) trial: secondary and post-hoc analyses
Robert Howard,Robert Howard,Rupert McShane,James Lindesay,Craig W. Ritchie,Ashley Baldwin,Robert Barber,Alistair Burns,Tom Dening,David Findlay,Clive Holmes,Robert G. Jones,Roy W. Jones,Ian G. McKeith,Ajay Macharouthu,John T. O'Brien,Bart Sheehan,Edmund Juszczak,Cornelius Katona,Robert Kerrin Hills,Martin Knapp,Clive Ballard,Richard G. Brown,Sube Banerjee,Jessica Adams,Tony Johnson,Peter Bentham,Patrick P. J. Phillips +27 more
TL;DR: Withdrawal of donepezil in patients with moderate-to-severe Alzheimer's disease increased the risk of nursing home placement during 12 months of treatment, but made no difference during the following 3 years of follow-up.
Journal ArticleDOI
Evaluating the effects of the novel GLP-1 analogue liraglutide in Alzheimer’s disease: study protocol for a randomised controlled trial (ELAD study)
Grazia Daniela Femminella,Eleni Frangou,Sharon Love,Gail Busza,Clive Holmes,Craig W. Ritchie,Robert M. Lawrence,Brady McFarlane,George Tadros,Basil H. Ridha,Carol Bannister,Zuzana Walker,Hilary Archer,Elizabeth Coulthard,Ben Underwood,Aparna Prasanna,Paul Koranteng,Salman Karim,Kehinde Junaid,Bernadette McGuinness,Ramin Nilforooshan,Ajay Macharouthu,Andrew Donaldson,Simon Thacker,Gregor Russell,Naghma Malik,Vandana Mate,Lucy Knight,Sajeev Kshemendran,John Harrison,John Harrison,David J. Brooks,David J. Brooks,Anthony Peter Passmore,Clive Ballard,Paul Edison,Paul Edison +36 more
TL;DR: If the ELAD trial is successful, liraglutide and GLP-1 analogues will represent an important class of compounds to be further evaluated in clinical trials for Alzheimer’s treatment.
Journal ArticleDOI
DOMINO-AD protocol: donepezil and memantine in moderate to severe Alzheimer's disease – a multicentre RCT
Robert G. Jones,Bart Sheehan,Patrick P. J. Phillips,Ed Juszczak,Jessica Adams,Ashley Baldwin,Clive Ballard,Subrata Banerjee,Bob Barber,Peter Bentham,Richard G. Brown,Alistair Burns,Tom Dening,David Findlay,Richard Gray,Mary Griffin,Clive Holmes,Alan Hughes,Robin Jacoby,Tony Johnson,Roy W. Jones,Martin Knapp,James Lindesay,Ian G. McKeith,Rupert McShane,Ajay Macharouthu,John T. O'Brien,Caroline Onions,Peter Passmore,James Raftery,Craig W. Ritchie,Robert Howard +31 more
TL;DR: The aim of this trial is to establish the most effective drug option for people with AD who are progressing from moderate to severe dementia despite treatment with donepezil, and to provide clear evidence on the best treatment strategies for those managing patients at a particularly important clinical transition point.