Institution
NHS Lanarkshire
Healthcare•Bothwell, United Kingdom•
About: NHS Lanarkshire is a healthcare organization based out in Bothwell, United Kingdom. It is known for research contribution in the topics: Health care & Population. The organization has 364 authors who have published 377 publications receiving 7134 citations. The organization is also known as: Lanarkshire NHS Board.
Papers published on a yearly basis
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Montreal General Hospital1, McGill University2, University of Pittsburgh3, SUNY Downstate Medical Center4, Toronto Western Hospital5, Johns Hopkins University School of Medicine6, University of Calgary7, University of Birmingham8, Hanyang University9, University College London10, NHS Lanarkshire11, Yeshiva University12, University of North Carolina at Chapel Hill13, Lund University14, University of Alabama at Birmingham15, Université de Montréal16, Dalhousie University17, University of British Columbia18, University of Western Ontario19, Royal University Hospital20, University of Manitoba21, Northwestern University22
TL;DR: The Lupus Survival Study Group data are reviewed and particularly the data from the State University of New York Health Science Center at Brooklyn, NY is reviewed.
Abstract: Objective. To examine mortality rates in the largest systemic lupus erythematosus (SLE) cohort ever assembled. Methods. Our sample was a multisite international SLE cohort (23 centers, 9,547 patients). Deaths were ascertained by vital statistics registry linkage. Standardized mortality ratio (SMR; ratio of deaths observed to deaths expected) estimates were calculated for-all deaths and by cause. The effects of sex, age, SLE duration, race, and calendar-year periods were determined. Results. The overall SMR was 2.4 (95% confidence interval 2.3-2.5). Particularly high mortality was seen for circulatory disease, infections, renal disease, non-Hodgkin's lymphoma, and lung cancer. The highest SMR estimates were seen in patient groups characterized by female sex, younger age, SLE duration < 1 year, or black/African American race. There was a dramatic decrease in total SMR estimates across calendar-year periods, which was demonstrable for specific causes including death due to infections and death due to renal disorders. However, the SMR due to circulatory diseases tended to increase slightly from the 1970s to the year 2001. Conclusion. Our data from a very large multicenter international cohort emphasize what has been demonstrated previously in smaller samples. These results highlight the increased mortality rate in SLE patients compared with the general population, and they suggest particular risk associated with female sex, younger age, shorter SLE duration, and black/African American race. The risk for certain types of deaths, primarily related to lupus activity (such as renal disease), has decreased over time, while the risk for deaths due to circulatory disease does not appear to have diminished. (Less)
940 citations
Montreal General Hospital1, McGill University2, NHS Lanarkshire3, University of Pittsburgh4, SUNY Downstate Medical Center5, Toronto Western Hospital6, Johns Hopkins University7, University of Calgary8, University of Birmingham9, Hanyang University10, Royal University Hospital11, University College London12, Yeshiva University13, University of North Carolina at Chapel Hill14, Lund University15, University of Alabama at Birmingham16, Université de Montréal17, Dalhousie University18, University of British Columbia19, University of Western Ontario20, University of Manitoba21, Northwestern University22
TL;DR: The results support the notion of an association between SLE and cancer and more precisely define the risk of non-Hodgkin's lymphoma in SLE.
Abstract: Objective There is increasing evidence in support of an association between systemic lupus erythematosus (SLE) and malignancy, but in earlier studies the association could not be quantified precisely The present study was undertaken to ascertain the incidence of cancer in SLE patients, compared with that in the general population Methods We assembled a multisite (23 centers) international cohort of patients diagnosed as having SLE Patients at each center were linked to regional tumor registries to determine cancer occurrence Standardized incidence ratios (SIRs) were calculated as the ratio of observed to expected cancers Cancers expected were determined by multiplying person-years in the cohort by the geographically matched age, sex, and calendar year-specific cancer rates, and summing over all person-years Results The 9,547 patients from 23 centers were observed for a total of 76,948 patient-years, with an average followup of 8 years Within the observation interval, 431 cancers occurred The data confirmed an increased risk of cancer among patients with SLE For all cancers combined, the SIR estimate was 115 (95% confidence interval [95% CI] 105-127), for all hematologic malignancies, it was 275 (95% CI 213-349), and for non-Hodgkin's lymphoma, it was 364 (95% CI 263-493) The data also suggested an increased risk of lung cancer (SIR 137; 95% CI 105-176), and hepatobiliary cancer (SIR 260; 95% CI 125, 478) Conclusion These results support the notion of an association between SLE and cancer and more precisely define the risk of non-Hodgkin's lymphoma in SLE It is not yet known whether this association is mediated by genetic factors or exogenous exposures
354 citations
Dalhousie University1, University of Toronto2, Hanyang University3, University of Birmingham4, University of California, Los Angeles5, University College London6, University of Alabama at Birmingham7, McGill University8, Oklahoma Medical Research Foundation9, Johns Hopkins University10, University of North Carolina at Chapel Hill11, University of Manchester12, University of Pittsburgh13, King's College London14, NHS Lanarkshire15, Columbia University16, SUNY Downstate Medical Center17, Karolinska Institutet18, Queen Elizabeth II Health Sciences Centre19, Lund University20, Northwestern University21, University of California, San Diego22, University of Cambridge23
TL;DR: Regardless of attribution, the occurrence of NP events was associated with reduced quality of life and increased organ damage, and those with NP events had lower scores on the SF-36 and higher SDI scores compared with patients with no NP events.
Abstract: Objective. To describe the prevalence, characteristics, attribution, and clinical significance of neuropsychiatric (NP) events in an international inception cohort of systemic lupus erythematosus (SLE) patients. Methods. The study was conducted by the Systemic Lupus International Collaborating Clinics (SLICC). Patients were enrolled within 15 months of fulfilling the American College of Rheumatology (ACR) SLE classification criteria. All NP events within a predefined enrollment window were identified using the ACR case definitions of 19 NP syndromes. Decision rules were derived to determine the proportion of NP disease attributable to SLE. Clinical significance was determined using the Short Form 36 (SF-36) Health Survey and the SLICC/ACR Damage Index (SDI). Results. A total of 572 patients (88% female) were recruited, with a mean +/- SD age of 35 +/- 14 years. The mean +/- SD disease duration was 5.2 +/- 4.2 months. Within the enrollment window, 158 of 572 patients (28%) had at least 1 NP event. In total, there were 242 NP events that encompassed 15 of 19 NP syndromes. The proportion of NP events attributed to SLE varied from 19% to 38% using alternate attribution models and occurred in 6.1-11.7% of patients. Those with NP events, regardless of attribution, had lower scores on the SF-36 and higher SDI scores compared with patients with no NP events. Conclusion. Twenty-eight percent of SLE patients experienced at least 1 NP event around the time of diagnosis of SLE, of which only a minority were attributed to SLE. Regardless of attribution, the occurrence of NP events was associated with reduced quality of life and increased organ damage. (Less)
275 citations
University of Leicester1, Pennsylvania State University2, Delft University of Technology3, University of Cassino4, University of Colorado Boulder5, Tallinn University of Technology6, University of Hong Kong7, National University of Singapore8, Queensland University of Technology9, Virginia Tech10, Technical University of Denmark11, University of California, Berkeley12, Aalborg University13, McGill University14, Edinburgh Napier University15, NHS Lanarkshire16
TL;DR: In this article, the authors present a review of the most commonly held dogmas on airborne transmission of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in the COVID-19 pandemic.
237 citations
McGill University Health Centre1, Northwestern University2, McGill University3, Johns Hopkins University School of Medicine4, NHS Lanarkshire5, Allegheny General Hospital6, Toronto Western Hospital7, Laval University8, SUNY Downstate Medical Center9, University of California, San Francisco10, Hanyang University11, University of California, Los Angeles12, University of Calgary13, University of Copenhagen14, University of Birmingham15, University of North Carolina at Chapel Hill16, University of Manitoba17, Dalhousie University18, University of Alabama at Birmingham19, Lund University20, University College London21, Hannover Medical School22, North Shore-LIJ Health System23, Medical University of South Carolina24, New York University25, Université de Montréal26, University of Western Ontario27, University of British Columbia28, Copenhagen University Hospital29, Royal University Hospital30
TL;DR: There is clearly an increased risk of NHL, and cancers of the vulva, lung, thyroid, and possibly liver in SLE relative to the general population, and it remains unclear to what extent the association with NHL is mediated by innate versus exogenous factors.
236 citations
Authors
Showing all 365 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Stephanie J. Dancer | 38 | 135 | 7000 |
| Asad Zoma | 32 | 66 | 9659 |
| Carl Elliott | 28 | 121 | 2829 |
| Ewan B. Macdonald | 24 | 85 | 1725 |
| Andrew McAuley | 24 | 105 | 2068 |
| Mark Barber | 21 | 45 | 1607 |
| Robin A.P. Weir | 16 | 53 | 1101 |
| Rachel Thorpe | 14 | 45 | 721 |
| Manish G. Patel | 13 | 23 | 1012 |
| Kathleen Duffy | 13 | 31 | 549 |
| Colin J. Petrie | 12 | 43 | 695 |
| Nicola Cogan | 10 | 41 | 519 |
| M Bryans | 10 | 18 | 815 |
| Ruth M Mellor | 9 | 14 | 288 |
| Anne Hendry | 9 | 23 | 245 |