Showing papers in "Clinical Gastroenterology and Hepatology in 2021"
TL;DR: An analysis of data from the Scientific Registry of Transplant Recipients found NASH to be the second most common indication for liver transplant in 2019, and the fastest increasing indication.
226Â citations
TL;DR: The change from NAFLD to MAFLD criteria may identify a greater number of individuals with metabolically complicated fatty liver and increased risk for CVD.
195Â citations
Stanford University1, Ochsner Medical Center2, Cornell University3, Harvard University4, University of Minnesota5, Hennepin County Medical Center6, Icahn School of Medicine at Mount Sinai7, University of California, San Francisco8, Brigham and Women's Hospital9, Beth Israel Deaconess Medical Center10, Duke University11, University of Pennsylvania12, Rush University Medical Center13, University of Michigan14, Veterans Health Administration15, University of Washington16, University of Arizona17, University of Kansas18, University Hospitals of Cleveland19, University of Southern California20, Mayo Clinic21, University of Pittsburgh22
TL;DR: The risk factors which predict higher overall mortality among patients with CLD and COVID-19 are ALD, decompensated cirrhosis and HCC.
163Â citations
TL;DR: In an analysis of incidence and mortality databases from 39 countries, it is found that the incidence of colon and rectal cancers has continued to increase in countries with medium-high HDI and in younger populations.
155Â citations
TL;DR: It is found that the gastrointestinal tract could be a route of transmission of SARS-CoV-2 even in patients with asymptomatic or mild disease, with no gastrointestinal symptoms.
144Â citations
TL;DR: This work summarizes data on worldwide incidence and mortality and analyze the 1975-2016 data from 9 registries of the National Cancer Institute's Surveillance, Epidemiology, and End Results study on the overall burden of pancreatic cancer as well as age-, sex-, and race-specific incidence, survival rates and trends.
138Â citations
TL;DR: Women to have a lower risk of nonalcoholic fatty liver disease than men, however, once NAFLD is established, women have a higher risk of advanced fibrosis than men-especially after age 50 years.
133Â citations
TL;DR: The new definition of MAFLD does not significantly change the prevalence compared with NAFLD, but it may reduce the incidence by 25%.
120Â citations
TL;DR: The effects of a low-fat, high-fiber diet vs an improved standard American diet, iSAD, included higher quantities of fruits, vegetables, and fiber than a typical SAD, increased quality of life and inflammation, and patients with UC remained in remission throughout the study period.
109Â citations
TL;DR: MAFLD criteria identified a significant group of people with more comorbidities and worse prognosis compared to those with NAFLD only, and should be considered in the general population to identify high-risk groups for early interventions.
94Â citations
TL;DR: In this paper, the vaccine-induced humoral and T-cell responses of these vulnerable patient groups were evaluated using an interferon-gamma release assay (EUROIMMUN) and a logistic regression analysis was performed to identify predictors of low response.
TL;DR: Patient-level risks of surgery have declined significantly over time, with 5-year cumulative risk of surgery of 7.0% in UC, and 18.
TL;DR: The data highlight the need to reorganize efforts against high-impact diseases such as CRC, considering possible future waves of SARS-CoV-2 or other pandemics, and also mortality if lasting beyond 12 months.
TL;DR: In evaluation of patients with suspected NAFLD, attenuation coefficient can identify patients with steatosis and liver stiffness can accurately detect fibrosis.
TL;DR: The results support the use of MRI-PDFF in non-invasive monitoring of treatment response in early-phase NASH clinical trials and provide helpful data for sample-size estimation for histology-based assessment.
TL;DR: A systematic literature review and meta-analysis of studies examining non-genetic risk factors for early-onset colorectal cancer (EoCRC), including demographic factors, comorbidities, and lifestyle factors was conducted by as mentioned in this paper.
TL;DR: In patients with NAFLD and compensated advanced chronic liver disease, baseline LSM and change in LSM are associated with risk of liver-related events and mortality.
TL;DR: Liver injury in patients with SARS-CoV-2 and chronic HBV co-infection was associated with severity and poor prognosis of disease, and liver function should be taken seriously and evaluated frequently.
Washington University in St. Louis1, Mount Sinai St. Luke's and Mount Sinai Roosevelt2, Medical College of Wisconsin3, Icahn School of Medicine at Mount Sinai4, Albert Einstein College of Medicine5, University of Chicago6, Steward Health Care System7, University of Central Florida8, Cedars-Sinai Medical Center9, Cleveland Clinic10
TL;DR: Real-world safety signals for tofacitinib are similar to those for clinical trials, with AEs reported from almost 16% of patients, support dose de-escalation after induction therapy, to reduce the risk of AEs.
TL;DR: A systematic review and meta-analysis of studies of patients with chronic HBV infection found that TDF treatment was associated with a significantly lower risk of HCC than entecavir treatment.
Medical University of South Carolina1, Emory University2, Vanderbilt University Medical Center3, Grady Memorial Hospital4, Michigan State University5, Saint Louis University6, University of Calgary7, The Ohio State University Wexner Medical Center8, Loma Linda University9, University of Southern California10, Washington University in St. Louis11, University of Miami12, University of Pittsburgh13, Anschutz Medical Campus14, Wake Forest University15, Boston Medical Center16, Beaumont Health17, Oakland University18, University Hospitals of Cleveland19, Northwestern University20, Columbia University Medical Center21, Indiana University22, Loyola University Medical Center23, Icahn School of Medicine at Mount Sinai24, Memorial Sloan Kettering Cancer Center25, Stony Brook University26, University of Virginia27, Henry Ford Health System28, Dartmouth College29, Veterans Health Administration30, University of Oklahoma Health Sciences Center31, University of California, Los Angeles32, Medical College of Wisconsin33, Johns Hopkins University34, McMaster University35, University of Manitoba36, University of Michigan37
TL;DR: Among patients hospitalized with COVID-19, gastrointestinal symptoms and liver test abnormalities were common but the majority were mild and their presence was not associated with a more severe clinical course.
TL;DR: In a prospective study, IGB appears to be safe and effective for NASH management when combined with a prescribed diet and exercise program and facilitated significant metabolic and histologic improvements in NASH.
TL;DR: In this paper, a systematic review and meta-analysis was performed to estimate the global prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) specifically in overweight and obese adults from the general population.
TL;DR: In patients with UC in endoscopic remission, persistent histologic activity is associated with higher rates of relapse, and greater degree of normalization may have a stronger impact.
TL;DR: The IM-UNITI study and long-term extension (LTE) as mentioned in this paper evaluated the longterm efficacy, safety, and immunogenicity of subcutaneous ustekinumab maintenance therapy in patients with Crohn's disease.
TL;DR: The global incidence of inflammatory bowel disease has increased considerably during the past few decades, and despite the current treatments available, many patients do not achieve remission.
TL;DR: Findings from studies of the effects of dietary patterns, single micronutrients, and food additives in inducing and maintaining remission in patients with IBD are reviewed.
TL;DR: Wang et al. as mentioned in this paper conducted a prospective, multi-center, single-blind randomized tandem colonoscopy study to evaluate a deep-learning based computer-aided polyp detection (CADe) system (EndoScreener, Shanghai Wision AI, China).
TL;DR: In NAFLD, LSM by MRE is a significant predictor of future development of cirrhosis and expands the role of MRE in clinical practice beyond the estimation of liver fibrosis and provides important evidence that improves individualized disease monitoring and patient counseling.
TL;DR: The results are consistent among different types of studies, in all patient subpopulations examined, and support the use of HBsAg seroclearance as a primary endpoint of trials of patients with chronic HBV infection.