M
Morten H. Vatn
Researcher at University of Oslo
Publications - 252
Citations - 19076
Morten H. Vatn is an academic researcher from University of Oslo. The author has contributed to research in topics: Inflammatory bowel disease & Population. The author has an hindex of 71, co-authored 250 publications receiving 17597 citations. Previous affiliations of Morten H. Vatn include Norwegian Institute of Public Health & University of California, San Francisco.
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Journal ArticleDOI
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
Carl A. Anderson,Gabrielle Boucher,Charlie W. Lees,Andre Franke,Mauro D'Amato,Kent D. Taylor,James Lee,Philippe Goyette,Marcin Imielinski,Anna Latiano,Caroline Lagacé,Regan Scott,Leila Amininejad,Suzannah Bumpstead,Leonard Baidoo,Robert N. Baldassano,Murray L. Barclay,Theodore M. Bayless,Stephan Brand,Carsten Büning,Jean-Frederic Colombel,Lee A. Denson,Martine De Vos,Marla Dubinsky,Cathryn Edwards,David Ellinghaus,Rudolf S N Fehrmann,James A B Floyd,Timothy H. Florin,Denis Franchimont,Lude Franke,Michel Georges,Jürgen Glas,Nicole L. Glazer,Stephen L. Guthery,Talin Haritunians,Nicholas K. Hayward,Jean-Pierre Hugot,Gilles Jobin,Debby Laukens,Ian C. Lawrance,Marc Lémann,Arie Levine,Cécile Libioulle,Edouard Louis,Dermot P.B. McGovern,Monica Milla,Grant W. Montgomery,Katherine I. Morley,Craig Mowat,Aylwin Ng,William G. Newman,Roel A. Ophoff,Laura Papi,Orazio Palmieri,Laurent Peyrin-Biroulet,Julián Panés,Anne M. Phillips,Natalie J. Prescott,Deborah D. Proctor,Rebecca L. Roberts,Richard K Russell,Paul Rutgeerts,Jeremy D. Sanderson,Miquel Sans,Philip Schumm,Frank Seibold,Yashoda Sharma,Lisa A. Simms,Mark Seielstad,Mark Seielstad,A. Hillary Steinhart,Stephan R. Targan,Leonard H. van den Berg,Morten H. Vatn,Hein W. Verspaget,Thomas D. Walters,Cisca Wijmenga,David C. Wilson,Harm-Jan Westra,Ramnik J. Xavier,Zhen Zhen Zhao,Cyriel Y. Ponsioen,Vibeke Andersen,Leif Törkvist,Maria Gazouli,Nicholas P. Anagnou,Tom H. Karlsen,Limas Kupčinskas,Jurgita Sventoraityte,John C. Mansfield,Subra Kugathasan,Mark S. Silverberg,Jonas Halfvarson,Jerome I. Rotter,Christopher G. Mathew,Anne M. Griffiths,Richard B. Gearry,Tariq Ahmad,Steven R. Brant,Mathias Chamaillard,Jack Satsangi,Judy H. Cho,Stefan Schreiber,Mark J. Daly,Jeffrey C. Barrett,Miles Parkes,Vito Annese,Hakon Hakonarson,Graham L. Radford-Smith,Richard H. Duerr,Severine Vermeire,Rinse K. Weersma,John D. Rioux +113 more
TL;DR: A meta-analysis of six ulcerative colitis genome-wide association study datasets found many candidate genes that provide potentially important insights into disease pathogenesis, including IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1.
Journal ArticleDOI
Mucosal Healing in Inflammatory Bowel Disease: Results From a Norwegian Population-Based Cohort
TL;DR: The present results give further strength to the use of mucosal healing as a clinical indicator and treatment goal in inflammatory bowel disease.
Journal ArticleDOI
Clinical course during the first 10 years of ulcerative colitis: results from a population-based inception cohort (IBSEN Study)
Inger Camilla Solberg,Idar Lygren,Jørgen Jahnsen,Erling Aadland,Ole Høie,Milada Cvancarova,Tomm Bernklev,Magne Henriksen,Jostein Sauar,Morten H. Vatn,Bjørn Moum +10 more
TL;DR: The prognosis for UC during the first 10 years was generally good, the colectomy rate was low, and a large proportion of patients were in remission as time progressed, suggesting patients with initially extensive colitis and elevated ESR could benefit from an early potent medical treatment strategy.
Journal ArticleDOI
Clinical course in Crohn's disease: results of a Norwegian population-based ten-year follow-up study.
Inger Camilla Solberg,Morten H. Vatn,Ole Høie,Njaal Stray,Jostein Sauar,Jørgen Jahnsen,Bjørn Moum,Idar Lygren +7 more
TL;DR: The prognosis for CD seems better than previously reported, the probability of surgery was low, and fewer than expected developed complicated disease behavior, and the finding of prognostic risk factors for subsequent surgery might call for attention to early effective medical treatment strategies.
Journal ArticleDOI
Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility
Andre Franke,Tobias Balschun,Tom H. Karlsen,Jurgita Sventoraityte,Susanna Nikolaus,Gabriele Mayr,Francisco S. Domingues,Mario Albrecht,Michael Nothnagel,David Ellinghaus,Christian Sina,Clive M. Onnie,Rinse K. Weersma,Pieter C. F. Stokkers,Cisca Wijmenga,Maria Gazouli,David P. Strachan,Wendy L. McArdle,Severine Vermeire,Paul Rutgeerts,Philip Rosenstiel,Michael Krawczak,Morten H. Vatn,Christopher G. Mathew,Stefan Schreiber +24 more
TL;DR: A genome-wide association study with 440,794 SNPs genotyped in 1,167 individuals with UC and 777 healthy controls strongly suggests that defective IL10 function is central to the pathogenesis of the UC subtype of IBD.