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Alan Y. Sakaguchi
Researcher at University of Texas Health Science Center at San Antonio
Publications - 77
Citations - 6155
Alan Y. Sakaguchi is an academic researcher from University of Texas Health Science Center at San Antonio. The author has contributed to research in topics: Gene & Chromosome. The author has an hindex of 29, co-authored 75 publications receiving 6057 citations. Previous affiliations of Alan Y. Sakaguchi include National Institutes of Health & University of Texas System.
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Journal ArticleDOI
A polymorphic DNA marker genetically linked to Huntington's disease
James F. Gusella,Nancy S. Wexler,P. Michael Conneally,S. L. Naylor,Mary Anne Anderson,Rudolph E. Tanzi,Paul C. Watkins,Kathleen Ottina,Margaret R. Wallace,Alan Y. Sakaguchi,Anne B. Young,Ira Shoulson,Ernesto Bonilla,Joseph B. Martin +13 more
TL;DR: The chromosomal localization of the Huntington's disease gene is the first step in using recombinant DNA technology to identify the primary genetic defect in this disorder.
Journal ArticleDOI
Human Lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization
Glenn Evan Nedwin,Susan L. Naylor,Alan Y. Sakaguchi,Douglas H. Smith,Julie Jarrett-Nedwin,Diane Pennica,David V. Goeddel,Patrick W. Gray +7 more
TL;DR: Human Tumor Necrosis Factor and Lymphotoxin are cytotoxic proteins which have similar biological activities and share 30 percent amino acid homology.
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Loss of heterozygosity of chromosome 3p markers in small-cell lung cancer
TL;DR: The data show loss of alleles of chromosome 3p markers in tumour DNA of all nine patients supporting the hypothesis that this region contributes to tumorigenesis in SCLC.
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Chromosome localization in normal human cells and neuroblastomas of a gene related to c- myc
Manfred Schwab,Harold E. Varmus,J. Michael Bishop,Karl Heinz Grzeschik,S. L. Naylor,Alan Y. Sakaguchi,Garrett M. Brodeur,Jeffrey M. Trent +7 more
TL;DR: Somatic cell hybrids are used to show that N-myc is normally localized on the distal short arm of chromosome 2, and in situ hybridization localizes amplified N- myc in neuroblastoma cells to homogeneously staining regions (HSRs) on different chromosomes.
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High-resolution chromosomal localization of human genes for amylase, proopiomelanocortin, somatostatin, and a DNA fragment (D3S1) by in situ hybridization
TL;DR: It is shown that the resolution of in situ hybridization can be increased by hybridizing the probe to stretched prometaphase chromosomes with high-resolution banding obtained after 5-bromodeoxyuridine treatment of the cells and with a Hoechst 33258/Giemsa chromosome-staining method.