P
Paul C. Watkins
Researcher at Life Technologies
Publications - 44
Citations - 7637
Paul C. Watkins is an academic researcher from Life Technologies. The author has contributed to research in topics: Chromosome 21 & Locus (genetics). The author has an hindex of 26, co-authored 44 publications receiving 7513 citations. Previous affiliations of Paul C. Watkins include Harvard University & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
A polymorphic DNA marker genetically linked to Huntington's disease
James F. Gusella,Nancy S. Wexler,P. Michael Conneally,S. L. Naylor,Mary Anne Anderson,Rudolph E. Tanzi,Paul C. Watkins,Kathleen Ottina,Margaret R. Wallace,Alan Y. Sakaguchi,Anne B. Young,Ira Shoulson,Ernesto Bonilla,Joseph B. Martin +13 more
TL;DR: The chromosomal localization of the Huntington's disease gene is the first step in using recombinant DNA technology to identify the primary genetic defect in this disorder.
Journal ArticleDOI
Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus
Rudolph E. Tanzi,James F. Gusella,Paul C. Watkins,G. A. P. Bruns,P. St. George-Hyslop,M L Van Keuren,D. Patterson,S. Pagan,David M. Kurnit,Rachael L. Neve +9 more
TL;DR: Overexpression of the gene in brain tissue from fetuses with Down syndrome (trisomy 21) can be explained by dosage since the locus encoding the beta protein maps to chromosome 21.
Journal ArticleDOI
The genetic defect causing familial Alzheimer's disease maps on chromosome 21
Peter St George-Hyslop,Rudolph E. Tanzi,Ronald J. Polinsky,Jonathan Haines,Linda Nee,Paul C. Watkins,Richard H. Myers,Richard H. Myers,Robert G. Feldman,Daniel A. Pollen,David A. Drachman,John H. Growdon,Amalia C. Bruni,Jean-François Foncin,Denise Salmon,P. Frommelt,Luigi Amaducci,Sandro Sorbi,Silva Piacentini,Gordon Stewart,Wendy Hobbs,P. Michael Conneally,James F. Gusella +22 more
TL;DR: The chromosomal location of this defective gene has been discovered by using genetic linkage to DNA markers on chromosome 21 and provides an explanation for the occurrence of Alzheimer's disease-like pathology in Down syndrome.
Journal ArticleDOI
Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder
P. St. George-Hyslop,Jonathan L. Haines,Lindsay A. Farrer,Ronald J. Polinsky,C. Van Broeckhoven,Alison Goate,D. R. Crapper McLachlan,Harry T. Orr,Amalia C. Bruni,Sandro Sorbi,Innocenzo Rainero,J. F. Foncin,Daniel A. Pollen,J. M. Cantu,Rossella Tupler,Rossella Tupler,Voskresenskaya Ni,Richard Mayeux,John H. Growdon,V. A. Fried,Richard H. Myers,Linda Nee,H Backhovens,J. J. Martin,Martin N. Rossor,M. J. Owen,Michael Mullan,M. E. Percy,H. Karlinsky,Stephen S. Rich,Leonard L. Heston,M.P. Montesi,M. Mortilla,N. Nacmias,James F. Gusella,John Hardy,K. Abe,Luigi Amaducci,L. Bergamini,Marc Bruyland,Stefano F. Cappa,Stefano F. Cappa,L. Connor,G. De Winter,David A. Drachman,Robert G. Feldman,M. Fracarro,M. Fracarro,M. E. Franco,P. Frommelt,Gavrilova Si,G. Gei,J. Gheuens,A. Haynes,J. Henry,L James,Marianne James,B. O'Donnell,Silvia Piacentini,L. Pinessi,P Roques,C. Ruiz,J. Swearer,Rudolph E. Tanzi,Antoon Vandenberghe,M. Vartanian,G. Vaula,Paul C. Watkins,Robert Williamson +68 more
TL;DR: The inheritance of five polymorphic DNA markers from the proximal long arm of chromosome 21 in a large unselected series of pedi-grees with familial Alzheimer's disease suggests that Alzheimer's Disease is not a single entity, but rather results from genetic defects on chromosome 21 and from other genetic or nongenetic factors.
Journal ArticleDOI
Hereditary spherocytosis associated with deletion of human erythrocyte ankyrin gene on chromosome 8.
Samuel E. Lux,William T. Tse,Joan C. Menninger,Kathryn M. John,Peter Harris,Oded Shalev,Robert R. Chilcote,Sally L. Marchesi,Paul C. Watkins,Vann Bennett,Sue Mclntosh,Francis S. Collins,Uta Francke,David C. Ward,Bernard G. Forget +14 more
TL;DR: The data suggest that defects or deficiency or ankyrin are responsible for HS at the SPH2 locus, and that one copy is missing from DNA of two unrelated children with severe HS and heterozygous deletions of chromosome 8 (del(8Xpll-p21.1)).