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Alane M. Gray
Researcher at Genentech
Publications - 53
Citations - 15765
Alane M. Gray is an academic researcher from Genentech. The author has contributed to research in topics: Gene & Peptide sequence. The author has an hindex of 32, co-authored 53 publications receiving 15489 citations. Previous affiliations of Alane M. Gray include Max Planck Society.
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Journal ArticleDOI
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells
Axel Ullrich,Lisa M. Coussens,Joel S. Hayflick,Thomas J. Dull,Alane M. Gray,A W Tam,Jeffrey E. Lee,Yosef Yarden,Towia A. Libermann,Joseph Schlessinger +9 more
TL;DR: The complete 1,210-amino acid sequence of the human epidermal growth factor (EGF) receptor precursor, deduced from cDNA clones derived from placental and A431 carcinoma cells, reveals close similarity between the entire predicted ν-erb-B mRNA oncogene product and the receptor transmembrane and cytoplasmic domains.
Journal ArticleDOI
Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes
Axel Ullrich,John Richard Bell,Ellson Y. Chen,R. Herrera,L. M. Petruzzelli,Thomas J. Dull,Alane M. Gray,Lisa M. Coussens,Yu Cheng Liao,M. Tsubokawa,Anthony J. Mason,Peter H. Seeburg,C. Grunfeld,Ora M. Rosen,J. Ramachandran,J. Ramachandran +15 more
TL;DR: The entire 1,370-amino-acid sequence of the human insulin receptor precursor is deduced from a single complementary DNA clone, finding sequence homologies to human epidermal growth factor receptor and the members of the src family of oncogene products.
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Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene.
Lisa M. Coussens,Teresa L. Yang-Feng,Yu Cheng Liao,Ellson Y. Chen,Alane M. Gray,John P. McGrath,Peter H. Seeburg,Towia A. Libermann,Joseph Schlessinger,Uta Francke,Arthur D. Levinson,Axel Ullrich +11 more
TL;DR: A novel potential cell surface receptor of the tyrosine kinase gene family has been identified and characterized by molecular cloning and its primary sequence is very similar to that of the human epidermal growth factor receptor and the v-erbB oncogene product.
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Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.
Axel Ullrich,Alane M. Gray,A W Tam,T Yang-Feng,M Tsubokawa,Clare E. Collins,William J. Henzel,T Le Bon,S Kathuria,Ellson Y. Chen +9 more
TL;DR: The complete primary structure of the human IGF‐I receptor from cloned cDNA is determined and the deduced sequence predicts a 1367 amino acid receptor precursor, including a 30‐residue signal peptide, which is removed during translocation of the nascent polypeptide chain.
Journal ArticleDOI
Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling
Ruey-Bing Yang,Melanie R. Mark,Alane M. Gray,Arthur J Huang,Ming Hong Xie,Min Zhang,Audrey Goddard,William I. Wood,Austin L. Gurney,Paul J. Godowski +9 more
TL;DR: It is shown that Toll-like receptor 2 (TLR2) is a signalling receptor that is activated by LPS in a response that depends on LPS-binding protein and is enhanced by CD14, and that TLR2 is a direct mediator of signalling by L PS.