Q
Qimin Zhan
Researcher at Peking Union Medical College
Publications - 212
Citations - 17015
Qimin Zhan is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: Cancer & DNA damage. The author has an hindex of 54, co-authored 186 publications receiving 15719 citations. Previous affiliations of Qimin Zhan include National Institutes of Health.
Papers
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Journal ArticleDOI
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
Michael B. Kastan,Qimin Zhan,Wafik S. El-Deiry,Tyler Jacks,William V. Walsh,Beverly Plunkett,Bert Vogelstein,Albert J. Fornace +7 more
TL;DR: Three participants are identified (AT gene(s), p53, and GADD45) in a signal transduction pathway that controls cell cycle arrest following DNA damage; abnormalities in this pathway probably contribute to tumor development.
Journal ArticleDOI
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
Martin Smith,I-Tsuen Chen,Qimin Zhan,Insoo Bae,Catheryne Chen,Tona M. Gilmer,Michael B. Kastan,Patrick M. O'Connor,Albert J. Fornace +8 more
TL;DR: Gadd45 was found to bind to PCNA, a normal component of Cdk complexes and a protein involved in DNA replication and repair, establishing GADD45 as a link between the p53-dependent cell cycle checkpoint and DNA repair.
Journal ArticleDOI
Identification of genomic alterations in oesophageal squamous cell cancer
Yongmei Song,Lin Li,Yunwei Ou,Zhibo Gao,En-Min Li,Xiangchun Li,Weimin Zhang,Jiaqian Wang,Li-Yan Xu,Yong Zhou,Xiao-Juan Ma,Lingyan Liu,Zitong Zhao,Xuanlin Huang,Jing Fan,Lijia Dong,Gang Chen,Liying Ma,Jie Yang,Chen Longyun,Minghui He,Li Miao,Xuehan Zhuang,Kai Huang,Kunlong Qiu,Guangliang Yin,Guangwu Guo,Qiang Feng,Peishan Chen,Zhi-Yong Wu,Jian-Yi Wu,Ling Ma,Jinyang Zhao,Longhai Luo,Ming Fu,Bainan Xu,Bo Chen,Yingrui Li,Tong Tong,Mingrong Wang,Zhihua Liu,Dongxin Lin,Xiuqing Zhang,Huanming Yang,Jun Wang,Qimin Zhan +45 more
TL;DR: Genomic analyses suggest that ESCC and head and neck squamous cell carcinoma share some common pathogenic mechanisms, and ESCC development is associated with alcohol drinking, and novel biological markers and tumorigenic pathways that would greatly improve therapeutic strategies for ESCC are explored.
Journal ArticleDOI
GADD45 induction of a G2/M cell cycle checkpoint
Xin Wei Wang,Qimin Zhan,Jill D. Coursen,M. A. Khan,H. U. Kontny,Lijia Yu,M C Hollander,Patrick M. O'Connor,Albert J. Fornace,Chris Harris +9 more
TL;DR: Genetic and physiological evidence of a Gadd45-mediated G2/M checkpoint was obtained by using GADD45-deficient human or murine cells, indicating that the mammalian genome is protected by a multiplicity of G 2/M checkpoints in response to specific types of DNA damage.
Journal Article
Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline
Saijun Fan,Martin Smith,Rivet Dj nd,Duba D,Qimin Zhan,Kurt W. Kohn,Albert J. Fornace,Patrick M. O'Connor +7 more
TL;DR: A combination of CDDP and pentoxifylline is capable of synergistic and preferential killing of p53-defective tumor cells that do not readily undergo apoptosis and suggested that cancer cells are more vulnerable to G2 checkpoint abrogators.