K
Karen van Eunen
Researcher at University Medical Center Groningen
Publications - 34
Citations - 5678
Karen van Eunen is an academic researcher from University Medical Center Groningen. The author has contributed to research in topics: Flux (metabolism) & Systems biology. The author has an hindex of 19, co-authored 31 publications receiving 4280 citations. Previous affiliations of Karen van Eunen include University of Groningen & Institute for Systems Biology.
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Journal ArticleDOI
The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism
Gijs den Besten,Karen van Eunen,Albert K. Groen,Koen Venema,Dirk-Jan Reijngoud,Barbara M. Bakker +5 more
TL;DR: This review summarizes the role of SCFAs in host energy metabolism, starting from the production by the gut microbiota to the uptake by the host and ending with the effects on host metabolism.
Journal ArticleDOI
Short-Chain Fatty Acids protect against High-Fat Diet-Induced Obesity via a PPARγ-dependent switch from lipogenesis to fat oxidation
Gijs den Besten,Aycha Bleeker,Albert Gerding,Karen van Eunen,Rick Havinga,Theo H. van Dijk,Maaike H. Oosterveer,Johan W. Jonker,Albert K. Groen,Dirk-Jan Reijngoud,Barbara M. Bakker +10 more
TL;DR: It is shown that dietary SCFAs induce a peroxisome proliferator–activated receptor-γ (PPARγ)–dependent switch from lipid synthesis to utilization, which demonstrates that adipose and hepatic PPARγ are critical mediators of the beneficial effects ofSCFAs on the metabolic syndrome.
Journal ArticleDOI
A systems study reveals concurrent activation of AMPK and mTOR by amino acids
Piero Dalle Pezze,Stefanie Ruf,Stefanie Ruf,Annika G Sonntag,Miriam Langelaar-Makkinje,Philip Hall,Alexander Martin Heberle,Patricia Razquin Navas,Patricia Razquin Navas,Karen van Eunen,Regine C Tölle,Jennifer J. Schwarz,Heike Wiese,Bettina Warscheid,Jana Deitersen,Björn Stork,Erik Fäßler,Sascha Schäuble,Udo Hahn,Peter Horvatovich,Daryl P. Shanley,Kathrin Thedieck,Kathrin Thedieck +22 more
TL;DR: It is found that aa acutely activate AMPK concurrently with mTOR, and it is shown that AMPK under aa sufficiency acts to sustain autophagy, which may be required to maintain protein homoeostasis and deliver metabolite intermediates for biosynthetic processes.
Journal ArticleDOI
Gut-derived short-chain fatty acids are vividly assimilated into host carbohydrates and lipids
Gijs den Besten,Katja Lange,Rick Havinga,Theo H. van Dijk,Albert Gerding,Karen van Eunen,Michael Müller,Albert K. Groen,Guido J. E. J. Hooiveld,Barbara M. Bakker,Dirk-Jan Reijngoud +10 more
TL;DR: Gut-derived acetate, propionate, and butyrate play important roles as substrates for glucose, cholesterol, and lipid metabolism and microarray data suggested that SCFAs exert a mild regulatory effect on the expression of genes involved in hepatic metabolic pathways during the 6-h infusion period.
Journal ArticleDOI
Measuring enzyme activities under standardized in vivo-like conditions for Systems Biology
Karen van Eunen,Jildau Bouwman,Pascale Daran-Lapujade,Jarne Postmus,André B. Canelas,Femke I. C. Mensonides,Rick Orij,Isil Tuzun,Joost van den Brink,Gertien J. Smits,Walter M. van Gulik,Stanley Brul,Joseph J. Heijnen,Johannes H. de Winde,M. Joost Teixeira de Mattos,Carsten Kettner,Jens Nielsen,Hans V. Westerhoff,Hans V. Westerhoff,Barbara M. Bakker,Barbara M. Bakker +20 more
TL;DR: A single assay medium for determining enzyme–kinetic parameters in yeast is developed that is as close as possible to the in’vivo situation for the yeast Saccharomyces cerevisiae, and at the same time is experimentally feasible.