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Albert K. Lee
Researcher at Howard Hughes Medical Institute
Publications - 38
Citations - 5601
Albert K. Lee is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Hippocampal formation & Prefrontal cortex. The author has an hindex of 21, co-authored 35 publications receiving 4222 citations. Previous affiliations of Albert K. Lee include Erasmus University Rotterdam & Humboldt State University.
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Journal ArticleDOI
Fully integrated silicon probes for high-density recording of neural activity
James J. Jun,Nicholas A. Steinmetz,Nicholas A. Steinmetz,Nicholas A. Steinmetz,Joshua H. Siegle,Daniel J. Denman,Marius Bauza,Brian Barbarits,Albert K. Lee,Costas A. Anastassiou,Costas A. Anastassiou,Alexandru Andrei,Cagatay Aydin,Mladen Barbic,Timothy J. Blanche,Vincent Bonin,João Couto,B. Dutta,Sergey L. Gratiy,Diego A. Gutnisky,Michael Häusser,Bill Karsh,Peter Ledochowitsch,Carolina Mora Lopez,Catalin Mitelut,Catalin Mitelut,Silke Musa,Michael S. Okun,Michael S. Okun,Michael S. Okun,Marius Pachitariu,Marius Pachitariu,Jan Putzeys,P. Dylan Rich,Cyrille Rossant,Cyrille Rossant,Wei-Lung Sun,Karel Svoboda,Matteo Carandini,Kenneth D. Harris,Kenneth D. Harris,Christof Koch,John O'Keefe,Timothy D. Harris +43 more
TL;DR: The fully integrated functionality and small size of Neuropixels probes allowed large populations of neurons from several brain structures to be recorded in freely moving animals and opens a path towards recording of brain-wide neural activity during behaviour.
Journal ArticleDOI
Memory of sequential experience in the hippocampus during slow wave sleep.
Albert K. Lee,Matthew A. Wilson +1 more
TL;DR: Rats repeatedly ran through a sequence of spatial receptive fields of hippocampal CA1 place cells in a fixed temporal order, consistent with evidence that the hippocampus is crucial for spatial learning in rodents and the formation of long-term memories of events in time in humans.
Journal ArticleDOI
Role of experience and oscillations in transforming a rate code into a temporal code
TL;DR: This work proposes a mechanism by which a temporal code can be generated through an interaction between an asymmetric rate code and oscillatory inhibition, and the resulting spike timing satisfies the temporal order constraints of hebbian learning.
Journal ArticleDOI
Neuropixels 2.0: A miniaturized high-density probe for stable, long-term brain recordings
Nicholas A. Steinmetz,Nicholas A. Steinmetz,Cagatay Aydin,Anna Lebedeva,Michael S. Okun,Michael S. Okun,Marius Pachitariu,Marius Bauza,Maxime Beau,Jai Bhagat,Claudia Böhm,Martijn Broux,Susu Chen,Jennifer Colonell,Richard J. Gardner,Bill Karsh,Fabian Kloosterman,Dimitar Kostadinov,Carolina Mora-Lopez,John O'Callaghan,Junchol Park,Jan Putzeys,Britton Sauerbrei,Rik van Daal,Abraham Z. Vollan,Shiwei Wang,Marleen Welkenhuysen,Zhiwen Ye,Joshua T. Dudman,B. Dutta,Adam W. Hantman,Kenneth D. Harris,Albert K. Lee,Edvard I. Moser,John O'Keefe,Alfonso Renart,Karel Svoboda,Michael Häusser,Sebastian Haesler,Sebastian Haesler,Matteo Carandini,Timothy D. Harris +41 more
TL;DR: A suite of electrophysiological tools comprising a miniaturized high-density probe, recoverable chronic implant fixtures, and algorithms for automatic post hoc motion correction are demonstrated, enabling an order-of-magnitude increase in the number of sites that can be recorded in small animals, such as mice, and the ability to record from them stably over long time scales.
Journal ArticleDOI
Intracellular determinants of hippocampal CA1 place and silent cell activity in a novel environment.
TL;DR: In this paper, the authors used whole-cell recording in freely moving rats exploring a novel maze, and observed differences in intrinsic cellular properties and input-based sub-threshold membrane potential levels underlying this division into place and silent cells.