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Albert K. Lee

Researcher at Howard Hughes Medical Institute

Publications -  38
Citations -  5601

Albert K. Lee is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Hippocampal formation & Prefrontal cortex. The author has an hindex of 21, co-authored 35 publications receiving 4222 citations. Previous affiliations of Albert K. Lee include Erasmus University Rotterdam & Humboldt State University.

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Memory of sequential experience in the hippocampus during slow wave sleep.

TL;DR: Rats repeatedly ran through a sequence of spatial receptive fields of hippocampal CA1 place cells in a fixed temporal order, consistent with evidence that the hippocampus is crucial for spatial learning in rodents and the formation of long-term memories of events in time in humans.
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Role of experience and oscillations in transforming a rate code into a temporal code

TL;DR: This work proposes a mechanism by which a temporal code can be generated through an interaction between an asymmetric rate code and oscillatory inhibition, and the resulting spike timing satisfies the temporal order constraints of hebbian learning.
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Neuropixels 2.0: A miniaturized high-density probe for stable, long-term brain recordings

TL;DR: A suite of electrophysiological tools comprising a miniaturized high-density probe, recoverable chronic implant fixtures, and algorithms for automatic post hoc motion correction are demonstrated, enabling an order-of-magnitude increase in the number of sites that can be recorded in small animals, such as mice, and the ability to record from them stably over long time scales.
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Intracellular determinants of hippocampal CA1 place and silent cell activity in a novel environment.

TL;DR: In this paper, the authors used whole-cell recording in freely moving rats exploring a novel maze, and observed differences in intrinsic cellular properties and input-based sub-threshold membrane potential levels underlying this division into place and silent cells.