A
Alberto Ciccia
Researcher at Columbia University
Publications - 47
Citations - 8065
Alberto Ciccia is an academic researcher from Columbia University. The author has contributed to research in topics: DNA damage & DNA repair. The author has an hindex of 22, co-authored 32 publications receiving 6744 citations. Previous affiliations of Alberto Ciccia include Columbia University Medical Center & Harvard University.
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Journal ArticleDOI
The DNA Damage Response: Making It Safe to Play with Knives
TL;DR: This review will focus on how the DDR controls DNA repair and the phenotypic consequences of defects in these critical regulatory functions in mammals.
Journal ArticleDOI
The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo
Kristen L. Meerbrey,Guang Hu,Jessica D. Kessler,Kevin Roarty,Mamie Z. Li,Justin E. Fang,Jason I. Herschkowitz,Anna E. Burrows,Alberto Ciccia,Tingting Sun,Earlene M. Schmitt,Ronald J. Bernardi,Xiaoyong Fu,Christopher S. Bland,Thomas A. Cooper,Rachel Schiff,Jeffrey M. Rosen,Thomas F. Westbrook,Stephen J. Elledge +18 more
TL;DR: The lentiviral pINDUCER series of expression vehicles enable tracking of viral transduction and shRNA or cDNA induction in a broad spectrum of mammalian cell types in vivo and allows isolation of cell populations that exhibit a potent, inducible target knockdown in vitro and in vivo that can be used in human xenotransplantation models to examine cancer drug targets.
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Identification of FAAP24, a Fanconi Anemia Core Complex Protein that Interacts with FANCM
Alberto Ciccia,Chen Ling,Rachel Coulthard,Zhijiang Yan,Yutong Xue,Amom Ruhikanta Meetei,El Houari Laghmani,Hans Joenje,Neil Q. McDonald,Johan P. de Winter,Weidong Wang,Stephen C. West +11 more
TL;DR: The data indicate that the FANCM/FAAP24 complex may play a key role in recruitment of the FA core complex to damaged DNA.
Journal ArticleDOI
Structural and Functional Relationships of the XPF/MUS81 Family of Proteins
TL;DR: Proteins belonging to the XPF/MUS81 family play important roles in the repair of DNA lesions caused by UV-light or DNA cross-linking agents and determining how they recognize specific DNA substrates and promote key repair reactions is an important challenge for the future.
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CRISPR-Mediated Base Editing Enables Efficient Disruption of Eukaryotic Genes through Induction of STOP Codons
Pierre Billon,Eric E. Bryant,Sarah A. Joseph,Tarun S. Nambiar,Samuel B. Hayward,Rodney Rothstein,Alberto Ciccia +6 more
TL;DR: It is shown that CRISPR-dependent base editing efficiently inactivates genes by precisely converting four codons (CAA, CAG, CGA, and TGG) into STOP codons without DSB formation, providing a comprehensive resource for DSB-free gene disruption by iSTOP.