Alberto M. Marmont

TL;DR: Bone marrow transplantation done in the chronic phase of chronic myelogenous leukemia offers some patients prolonged leukemia-free survival, and the T-cell-depleted grafts are associated with an increased probability of relapse.

TL;DR: Among recipients of T-cell-depleted transplants for early leukemia, radiation doses greater than or equal to 11 Gy, dose rates greater than 14 cGy/min, and additional posttransplant immune suppression with cyclosporine alone or methotrexate were associated with fewer treatment failures but use of monoclonal antibodies rather than physical techniques for T- cell depletion and fractionated radiation was associated with increased treatment failure and lower leukemia-free survival.

TL;DR: Analysis of data from 2036 recipients of HLA‐identical sibling transplants for leukaemia or aplastic anaemia indicates that grading of GvHD can be reproducibly divided into absent or mild versus moderate to severe; 2‐year actuarial probability was 54% (95% confidence interval 52–56%) for Absent or mild and 46% (44–48%) formoderate to severe.

TL;DR: This largest cohort studied worldwide shows that autologous hematopoietic stem cell transplantation can induce sustained remissions for more than 5 years in patients with severe autoimmune diseases refractory to conventional therapy.