Journal ArticleDOI
T-cell depletion of HLA-identical transplants in leukemia.
Alberto M. Marmont,Mary M. Horowitz,Robert Peter Gale,Kathleen A. Sobocinski,Robert C. Ash,D. W. van Bekkum,Richard E. Champlin,Karel A. Dicke,John M. Goldman,R.A. Good +9 more
TLDR
Among recipients of T-cell-depleted transplants for early leukemia, radiation doses greater than or equal to 11 Gy, dose rates greater than 14 cGy/min, and additional posttransplant immune suppression with cyclosporine alone or methotrexate were associated with fewer treatment failures but use of monoclonal antibodies rather than physical techniques for T- cell depletion and fractionated radiation was associated with increased treatment failure and lower leukemia-free survival.About:
This article is published in Blood.The article was published on 1991-10-15. It has received 789 citations till now. The article focuses on the topics: Acute leukemia & Chronic phase chronic myelogenous leukemia.read more
Citations
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Journal ArticleDOI
Graft-versus-host disease
TL;DR: The understanding of the risk factors and causes of GHVD, the cellular and cytokine networks implicated in its pathophysiology, and current strategies to prevent and treat the disease are reviewed.
Journal ArticleDOI
Hematopoietic cell transplantation in older patients with hematologic malignancies: replacing high-dose cytotoxic therapy with graft-versus-tumor effects
Peter A. McSweeney,Peter A. McSweeney,Peter A. McSweeney,Dietger Niederwieser,Dietger Niederwieser,Dietger Niederwieser,Judith A. Shizuru,Judith A. Shizuru,Judith A. Shizuru,Brenda M. Sandmaier,Brenda M. Sandmaier,Brenda M. Sandmaier,Arthur J. Molina,Arthur J. Molina,Arthur J. Molina,David G. Maloney,David G. Maloney,David G. Maloney,Thomas R. Chauncey,Thomas R. Chauncey,Thomas R. Chauncey,Ted Gooley,Ted Gooley,Ted Gooley,U Hegenbart,U Hegenbart,U Hegenbart,Richard A. Nash,Richard A. Nash,Richard A. Nash,Jerald P. Radich,Jerald P. Radich,Jerald P. Radich,John L. Wagner,John L. Wagner,John L. Wagner,Steven Minor,Steven Minor,Steven Minor,Frederick R. Appelbaum,Frederick R. Appelbaum,Frederick R. Appelbaum,William I. Bensinger,William I. Bensinger,William I. Bensinger,Eileen Bryant,Eileen Bryant,Eileen Bryant,Mary E.D. Flowers,Mary E.D. Flowers,Mary E.D. Flowers,George E. Georges,George E. Georges,George E. Georges,F. Carl Grumet,F. Carl Grumet,F. Carl Grumet,Hans-Peter Kiem,Hans-Peter Kiem,Hans-Peter Kiem,Beverly Torok-Storb,Beverly Torok-Storb,Beverly Torok-Storb,Cong Yu,Cong Yu,Cong Yu,Karl G. Blume,Karl G. Blume,Karl G. Blume,Rainer Storb,Rainer Storb,Rainer Storb +71 more
TL;DR: A novel allografting approach, based on the use of postgrafting immunosuppression to control graft rejection and GVHD, has dramatically reduced the acute toxicities of allogRAFTing.
Journal ArticleDOI
Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype.
Franco Aversa,Antonio Tabilio,Andrea Velardi,Cunningham I,Adelmo Terenzi,F. Falzetti,Loredana Ruggeri,G. Barbabietola,Cynthia Aristei,Paolo Latini,Yair Reisner,M F Martelli +11 more
TL;DR: The main limitations of transplantation of bone marrow from donors who are matched with the recipient for only one HLA haplotype GVHD and graft failure - can be overcome.
Book ChapterDOI
Graft-Versus-Host Disease
J. Jansen,Q. Chang,L. P. Akard +2 more
TL;DR: Two studies with mice, dogs, and monkeys established a “bone marrow syndrome” with death through the complications of pancytopenia after a total body dose of 5–7 Gy (500–700 rad), and were trailblazers for bone marrow transplantation as therapeutic modality in man.
Journal ArticleDOI
Donor characteristics as risk factors in recipients after transplantation of bone marrow from unrelated donors: the effect of donor age
Craig Kollman,Craig W. S. Howe,Claudio Anasetti,Joseph H. Antin,Stella M. Davies,Alexandra H. Filipovich,J Hegland,Naynesh Kamani,Nancy A. Kernan,Roberta King,Voravit Ratanatharathorn,Daniel J. Weisdorf,Dennis L. Confer +12 more
TL;DR: Age should be considered when selecting among comparably HLA-matched volunteer donors and the use of younger donors may lower the incidence of GVHD and improve survival after bone marrow transplantation.
References
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Book ChapterDOI
Regression Models and Life-Tables
TL;DR: The analysis of censored failure times is considered in this paper, where the hazard function is taken to be a function of the explanatory variables and unknown regression coefficients multiplied by an arbitrary and unknown function of time.
Journal ArticleDOI
Graft-versus-leukemia reactions after bone marrow transplantation
Mary M. Horowitz,Robert Peter Gale,Paul M. Sondel,John M. Goldman,J. H. Kersey,HJ Kolb,A. A. Rimm,O Ringden,C. Rozman,Bruno Speck +9 more
TL;DR: The results explain the efficacy of allogeneic bone marrow transplantation in eradicating leukemia, provide evidence for a role of the immune system in controlling human cancers, and suggest future directions to improve leukemia therapy.
Journal ArticleDOI
Antileukemic Effect of Graft-versus-Host Disease in Human Recipients of Allogeneic-Marrow Grafts
TL;DR: The apparent antileukemic effect was more marked in patients with lymphoblastic than nonlymphoblastic leukemia, and in those who received transplants during relapse rather than during remission, and was most evident during the first 130 days after transplantation.
Journal ArticleDOI
The analysis of failure times in the presence of competing risks.
Ross L. Prentice,John D. Kalbfleisch,A. V. Peterson,Nancy Flournoy,Vernon T. Farewell,Norman E. Breslow +5 more
TL;DR: It is argued that the problem of estimation of failure rates under the removal of certain causes is not well posed until a mechanism for cause removal is specified, and a method involving the estimation of parameters that relate time-dependent risk indicators for some causes to cause-specific hazard functions for other causes is proposed for the study of interrelations among failure types.