抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Wetting phenomena are ubiquitous in nature and technology. A solid substrate exposed to the environment is almost invariably covered by a layer of fluid material. In this review, the surface forces that lead to wetting are considered, and the equilibrium surface coverage of a substrate in contact with a drop of liquid. Depending on the nature of the surface forces involved, different scenarios for wetting phase transitions are possible; recent progress allows us to relate the critical exponents directly to the nature of the surface forces which lead to the different wetting scenarios. Thermal fluctuation effects, which can be greatly enhanced for wetting of geometrically or chemically structured substrates, and are much stronger in colloidal suspensions, modify the adsorption singularities. Macroscopic descriptions and microscopic theories have been developed to understand and predict wetting behavior relevant to microfluidics and nanofluidics applications. Then the dynamics of wetting is examined. A drop, placed on a substrate which it wets, spreads out to form a film. Conversely, a nonwetted substrate previously covered by a film dewets upon an appropriate change of system parameters. The hydrodynamics of both wetting and dewetting is influenced by the presence of the three-phase contact line separating "wet" regions from those that are either dry or covered by a microscopic film only. Recent theoretical, experimental, and numerical progress in the description of moving contact line dynamics are reviewed, and its relation to the thermodynamics of wetting is explored. In addition, recent progress on rough surfaces is surveyed. The anchoring of contact lines and contact angle hysteresis are explored resulting from surface inhomogeneities. Further, new ways to mold wetting characteristics according to technological constraints are discussed, for example, the use of patterned surfaces, surfactants, or complex fluids.

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Wetting and Spreading

Annual review of condensed matter physics

Journal of Statistical Mechanics: theory and experiment

Tables of integrals

We study the directed polymer of length t in a random potential with fixed endpoints in dimension 1+1 in the continuum and on the square lattice, by analytical and numerical methods. The universal regime of high temperature T is described, upon scaling "time"t~T5/κ and space x=T3/κ (with κ=T for the discrete model) by a continuum model with δ-function disorder correlation. Using the Bethe Ansatz solution for the attractive boson problem, we obtain all positive integer moments of the partition function. The lowest cumulants of the free energy are predicted at small time and found in agreement with numerics. We then obtain the exact expression at any time for the generating function of the free-energy distribution, in terms of a Fredholm determinant. At large time we find that it crosses over to the Tracy-Widom distribution (TW) which describes the fixed-T infinite-t limit. The exact free-energy distribution is obtained for any time and compared with very recent results on growth and exclusion models.

/pdf/free-energy-distribution-of-the-directed-polymer-at-high-1isui8h2o0.pdf

Free-energy distribution of the directed polymer at high temperature

We study the directed polymer of length $t$ in a random potential with fixed endpoints in dimension 1+1 in the continuum and on the square lattice, by analytical and numerical methods. The universal regime of high temperature $T$ is described, upon scaling 'time' $t \sim T^5/\kappa$ and space $x = T^3/\kappa$ (with $\kappa=T$ for the discrete model) by a continuum model with $\delta$-function disorder correlation. Using the Bethe Ansatz solution for the attractive boson problem, we obtain all positive integer moments of the partition function. The lowest cumulants of the free energy are predicted at small time and found in agreement with numerics. We then obtain the exact expression at any time for the generating function of the free energy distribution, in terms of a Fredholm determinant. At large time we find that it crosses over to the Tracy Widom distribution (TW) which describes the fixed $T$ infinite $t$ limit. The exact free energy distribution is obtained for any time and compared with very recent results on growth and exclusion models.

We combine an analytically solvable mean-field elasto-plastic model with molecular dynamics simulations of a generic glass former to demonstrate that, depending on their preparation protocol, amorphous materials can yield in two qualitatively distinct ways. We show that well-annealed systems yield in a discontinuous brittle way, as metallic and molecular glasses do. Yielding corresponds in this case to a first-order nonequilibrium phase transition. As the degree of annealing decreases, the first-order character becomes weaker and the transition terminates in a second-order critical point in the universality class of an Ising model in a random field. For even more poorly annealed systems, yielding becomes a smooth crossover, representative of the ductile rheological behavior generically observed in foams, emulsions, and colloidal glasses. Our results show that the variety of yielding behaviors found in amorphous materials does not necessarily result from the diversity of particle interactions or microscopic dynamics but is instead unified by carefully considering the role of the initial stability of the system.

Random critical point separates brittle and ductile yielding transitions in amorphous materials

The fractional Laplacian operator -(-delta)(alpha/2) appears in a wide class of physical systems, including Levy flights and stochastic interfaces. In this paper, we provide a discretized version of this operator which is well suited to deal with boundary conditions on a finite interval. The implementation of boundary conditions is justified by appealing to two physical models, namely, hopping particles and elastic springs. The eigenvalues and eigenfunctions in a bounded domain are then obtained numerically for different boundary conditions. Some analytical results concerning the structure of the eigenvalue spectrum are also obtained.

/pdf/fractional-laplacian-in-bounded-domains-gb1234fni2.pdf

Fractional Laplacian in bounded domains.

Yield stress materials flow if a sufficiently large shear stress is applied. Although such materials are ubiquitous and relevant for industry, there is no accepted microscopic description of how they yield, even in the simplest situations in which temperature is negligible and in which flow inhomogeneities such as shear bands or fractures are absent. Here we propose a scaling description of the yielding transition in amorphous solids made of soft particles at zero temperature. Our description makes a connection between the Herschel-Bulkley exponent characterizing the singularity of the flow curve near the yield stress Σc, the extension and duration of the avalanches of plasticity observed at threshold, and the density P(x) of soft spots, or shear transformation zones, as a function of the stress increment x beyond which they yield. We argue that the critical exponents of the yielding transition may be expressed in terms of three independent exponents, θ, df, and z, characterizing, respectively, the density of soft spots, the fractal dimension of the avalanches, and their duration. Our description shares some similarity with the depinning transition that occurs when an elastic manifold is driven through a random potential, but also presents some striking differences. We test our arguments in an elasto-plastic model, an automaton model similar to those used in depinning, but with a different interaction kernel, and find satisfying agreement with our predictions in both two and three dimensions.

/pdf/scaling-description-of-the-yielding-transition-in-soft-2dtgcfyrkz.pdf

Alberto Rosso

Papers

Free-energy distribution of the directed polymer at high temperature

Free-energy distribution of the directed polymer at high temperature

Random critical point separates brittle and ductile yielding transitions in amorphous materials

Fractional Laplacian in bounded domains.

Scaling description of the yielding transition in soft amorphous solids at zero temperature