M
Mitchell Goldfarb
Researcher at Hunter College
Publications - 116
Citations - 16779
Mitchell Goldfarb is an academic researcher from Hunter College. The author has contributed to research in topics: Fibroblast growth factor & Gene. The author has an hindex of 56, co-authored 103 publications receiving 16340 citations. Previous affiliations of Mitchell Goldfarb include City University of New York & The Graduate Center, CUNY.
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Journal ArticleDOI
Receptor specificity of the fibroblast growth factor family.
David M. Ornitz,Jingsong Xu,Jennifer S. Colvin,Donald G. McEwen,Craig A. MacArthur,François Coulier,Guangxia Gao,Mitchell Goldfarb +7 more
TL;DR: It is demonstrated that FGF 1 is the only FGF that can activate all FGF receptor splice variants and the relative activity of all the other members of the FGF family is determined.
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Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity.
Samuel Davis,Nicholas W. Gale,Aldrich Thomas H,Maisonpierre Peter C,Vladimir Lhotak,Tony Pawson,Mitchell Goldfarb,George D. Yancopoulos +7 more
TL;DR: A family of cell surface-bound ligands exhibiting distinct, but overlapping, specificities for these EPH-related kinases was identified, suggesting that they require direct cell-to-cell contact to activate their receptors.
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Requirement of FGF-4 for postimplantation mouse development
Benjamin E. Feldman,William Poueymirou,Virginia E. Papaioannou,Thomas M. Dechiara,Mitchell Goldfarb +4 more
TL;DR: Embryos homozygous for the null allele underwent uterine implantation and induced uterine decidualization but did not develop substantially thereafter, and growth and differentiation of the inner cell mass were rescued when null embryos were cultured in the presence of FGF-4 protein.
Journal ArticleDOI
Initiation of Mammalian Liver Development from Endoderm by Fibroblast Growth Factors
TL;DR: Different FGF signals appear to initiate distinct phases of liver development during mammalian organogenesis, and studies with FGFs and their specific inhibitors showed that FGF8 contributes to the morphogenetic outgrowth of the hepatic endoderm.
Journal ArticleDOI
The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases
Trevor Stitt,Greg Conn,Martin Goret,Martin Goret,Cary Lai,Joanne Bruno,Czeslaw Radzlejewski,Karen Mattsson,John Fisher,David R. Gies,Pamela F. Jones,Piotr Masiakowski,Terence E Ryan,Nancy J Tobkes,D.H Chen,Peter S. DiStefano,George L. Long,Claudio Basilico,Mitchell Goldfarb,Greg Lemke,David J. Glass,George D. Yancopoulos +21 more
TL;DR: The identification of ligands for Tyro 3 and Axl (alternatively, Ark or UFO), members of a previously orphan family of receptor-like tyrosine kinases, correspond to protein S, a protease regulator that is a potent anticoagulant, and Gas6, a protein related toprotein S but lacking any known function.