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Aleksandra Trifunovic
Researcher at University of Cologne
Publications - 94
Citations - 9155
Aleksandra Trifunovic is an academic researcher from University of Cologne. The author has contributed to research in topics: Mitochondrion & Mitochondrial DNA. The author has an hindex of 30, co-authored 80 publications receiving 7840 citations. Previous affiliations of Aleksandra Trifunovic include Max Planck Society & Karolinska Institutet.
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Journal ArticleDOI
Strong Purifying Selection in Transmission of Mammalian Mitochondrial DNA
James B. Stewart,Christoph Freyer,Joanna L. Elson,Anna Wredenberg,Zekiye Cansu,Aleksandra Trifunovic,Nils-Göran Larsson +6 more
TL;DR: This study presents the first direct experimental observations of the fate of random mtDNA mutations in the mammalian germ line and demonstrates the importance of purifying selection in shaping mitochondrial sequence diversity.
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Proteolytic processing of OPA1 links mitochondrial dysfunction to alterations in mitochondrial morphology.
Stéphane Duvezin-Caubet,Ravi Jagasia,Johannes Wagener,Sabine Hofmann,Aleksandra Trifunovic,Anna Hansson,Anne Chomyn,Matthias F. Bauer,Giuseppe Attardi,Nils-Göran Larsson,Walter Neupert,Andreas S. Reichert +11 more
TL;DR: The hypothesis that this pathway regulates mitochondrial morphology and serves as an early response to prevent fusion of dysfunctional mitochondria with the functional mitochondrial network is presented.
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Mitochondrial dysfunction as a cause of ageing.
TL;DR: Mitochondrial dysfunction is clearly involved in the human ageing process, but its relative importance for mammalian ageing remains to be established.
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Mitochondrial DNA polymerase gamma is essential for mammalian embryogenesis
TL;DR: Results show that Polg indeed is the only DNA polymerase capable of maintaining mtDNA in mammalian mitochondria, and presence of Polg is absolutely essential for the organogenesis during mammalian embryonic development.
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Somatic Progenitor Cell Vulnerability to Mitochondrial DNA Mutagenesis Underlies Progeroid Phenotypes in Polg Mutator Mice
Kati J. Ahlqvist,Riikka H. Hämäläinen,Shuichi Yatsuga,Marko Uutela,Mügen Terzioglu,Alexandra Götz,Saara Forsström,Petri Salven,Alexandre Angers-Loustau,Outi H. Kopra,Henna Tyynismaa,Nils-Göran Larsson,Kirmo Wartiovaara,Tomas A. Prolla,Aleksandra Trifunovic,Anu Suomalainen +15 more
TL;DR: This work proposes that SSC compartment is sensitive to mtDNA mutagenesis, and that mitochondrial dysfunction in SSCs can underlie progeroid manifestations, and proposes that N-acetyl-L-cysteine treatment rescued both NSC and HPC abnormalities.