A
Alessandra Geremia
Researcher at University of Oxford
Publications - 42
Citations - 2706
Alessandra Geremia is an academic researcher from University of Oxford. The author has contributed to research in topics: Inflammatory bowel disease & Crohn's disease. The author has an hindex of 19, co-authored 40 publications receiving 2261 citations. Previous affiliations of Alessandra Geremia include John Radcliffe Hospital & University of Rome Tor Vergata.
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Journal ArticleDOI
Innate and adaptive immunity in inflammatory bowel disease
TL;DR: In this paper, the authors investigated the role of the adaptive immune response in the pathogenesis of Crohn's disease and ulcerative colitis (UC) and found that an abnormal immune response against the microorganisms of the intestinal flora is responsible for the disease in genetically susceptible individuals.
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IL-23–responsive innate lymphoid cells are increased in inflammatory bowel disease
Alessandra Geremia,Carolina V. Arancibia-Cárcamo,M Fleming,Nigel A. Rust,Baljit Singh,Neil Mortensen,Simon Travis,Fiona Powrie +7 more
TL;DR: Increased numbers of innate lymphoid cells in patients with inflammatory bowel disease are found to be associated with better prognosis and decreased likelihood of long-term disease progression.
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Human MAIT and CD8αα cells develop from a pool of type-17 precommitted CD8 + T cells
Lucy J. Walker,Yu-Hoi Kang,Matthew O. Smith,Hannah Tharmalingham,Narayan Ramamurthy,Vicki M. Fleming,Natasha Sahgal,Alistair Leslie,Ye Oo,Alessandra Geremia,Thomas J. Scriba,Willem A. Hanekom,Georg M. Lauer,Olivier Lantz,David H. Adams,Fiona Powrie,Eleanor Barnes,Paul Klenerman +17 more
TL;DR: The origin and differentiation pathway of MAIT-cells from a naive type-17 precommitted CD161(++)CD8(+) T-cell pool and the distinct phenotype and function of CD8αα cells in man are demonstrated.
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Infliximab and newly diagnosed neoplasia in Crohn’s disease: a multicentre matched pair study
Livia Biancone,Ambrogio Orlando,Anna Kohn,Enrico Colombo,R. Sostegni,E. Angelucci,Fernando Rizzello,Fabiana Castiglione,L. Benazzato,Claudio Papi,Gianmichele Meucci,Gabriele Riegler,Carmelina Petruzziello,F. Mocciaro,Alessandra Geremia,Emma Calabrese,Mario Cottone,Francesco Pallone +17 more
TL;DR: In a multicentre matched pair study, the frequency of a new diagnosis of neoplasia in Crohn’s disease patients treated with Infliximab was comparable with CD patients who had never received InNetfliximab.
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Innate Lymphoid Cells in Intestinal Inflammation.
TL;DR: Results from animal models of colitis and human studies indicate a role for innate lymphoid cells (ILC) in the pathogenesis of chronic intestinal inflammation in IBD and IBD-associated cancer.